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End-to-end reconstruction for cryo electron ptychographic single-particle analysis

This paper introduces an end-to-end reconstruction algorithm for cryo-ptycho single-particle analysis, achieving better resolution than sequential methods on simulated data and some experimental datasets.

MaCADEMIA: a software toolbox for single-molecule fluorescence image quantification

MaCADEMIA is a MATLAB toolbox for single-molecule fluorescence image analysis, providing accurate quantification of molecular properties in living cells.

Age-based shifts in multicellular community organization and abundance in HPV-Negative Head and Neck Cancer

This study identifies age-related changes in cellular composition and organization in HPV-negative head and neck cancer using single-cell data, highlighting MDK as a key factor in stromal remodeling and immunosuppression.

Raman-probe-derived biomarkers account for cartilage composition, structure, and viscoelastic properties

This study uses Raman spectroscopy to identify biomarkers that correlate with cartilage composition, structure, and viscoelastic properties in equine osteochondral explants.

The Effects of Environmental Enrichment on the Behavior of Laboratory Zebrafish (Danio rerio).

This study examines how different environmental enrichments affect adult zebrafish behavior, finding reduced aggression with enrichment but no significant impact on reproduction or growth.

CYP123, a sterol C4-methyl oxidase, acts with CYP51 to initiate mycobacterial lanosterol catabolism

This study identifies CYP123 as a key enzyme in mycobacterial lanosterol catabolism, showing it works with CYP51 to oxidize C14-demethylated sterols, expanding the known sterol utilization beyond cholesterol.

The cyclin-G associated kinase (GAK) is a novel mitotic kinase and therapeutic target in diffuse large B-cell lymphoma

This paper identifies GAK as a novel mitotic kinase and therapeutic target in DLBCL, showing that GAK inhibition causes mitotic defects and that existing drugs can be repurposed for its targeting.

Harmonizing Repeated Multi-Platform Optical and LiDAR Observations for Continental-Scale Terrestrial Carbon Cycle Data Assimilation.

This study integrates GEDI LiDAR with an existing data assimilation system to improve terrestrial carbon monitoring, reducing woody biomass uncertainty by 63.7% and achieving RMSE reduction of 38.3 kg/m2.

Identifying the source population of naturally recolonised rhinoceros (Rhinoceros unicornis) in Laokhowa-Burhachapori Wildlife Sanctuary, Assam, through multidisciplinary methods

The paper identifies the source population of recolonized rhinoceros in Laokhowa-Burhachapori WLS using genetic and landscape connectivity analyses, finding Orang NP as the likely source.

Cell-resolved pharmacodynamic profiling reveals tissue- and cell-population-specific activity of antisense oligonucleotide chemical conjugates in vivo

This study evaluates cell-specific activity of antisense oligonucleotide conjugates in vivo using a reporter mouse model and finds that palmitate conjugation shows broad extrahepatic activity and preferential skeletal muscle targeting.

Fertilization offsets the maternal age effect on mouse oocytes provided the oviduct is not itself aged

This study shows that fertilization can reverse the negative effects of maternal age on oocyte quality in mice, provided the fertilization environment is not aged.

PFOS and GenX Induce Mitochondrial Toxicity and Differentially Alter Respiratory Complex Activities in Liver and Brain

This study examines how PFOS and GenX affect mitochondrial respiratory complex activities in liver and brain under different exposure conditions, showing exposure-dependent and tissue-specific effects.

The transformer as a candidate canonical cortical microcircuit

The paper compares transformer architectures to cortical microcircuits, finding that transformers uniquely capture circuit details, functional maps, and wiring efficiency.

An Integrated Experimental and Informatics Strategy Enables Large Proteoform Identification in Top-Down Proteomics

The paper presents an integrated experimental and informatics strategy to improve identification of large proteoforms in top-down proteomics, achieving identification of proteoforms up to 223 kDa.

Decoding antibody-antigen recognition: the BL8 language and its application in calibrating deep learning predictions

This paper introduces BL8, a structural language to evaluate deep learning predictions of antibody-antigen interactions, revealing false positives and enabling reliable consensus predictions.

Genomic context tunes sequence-encoded RNA processing

The paper shows that genomic context influences RNA processing by demonstrating that introns retain splicing across ectopic positions, while cryptic polyadenylation sites are less frequently used outside their native context.

TROP2 and immune gene expression by African ancestry in triple-negative breast cancer

The paper examines TROP2 and immune gene expression differences by African ancestry in TNBC, finding no significant TACSTD2 differences by race or ancestry but a link between higher African ancestry and higher PDCD1 expression.

Host identity drives distinct prokaryotic and microeukaryotic microbiomes across four cold-water coral species in a near-pristine Mediterranean reef.

The paper characterizes prokaryotic and microeukaryotic microbiomes of four cold-water corals, finding host identity as the main driver of microbial community structure.

De novo design of mini-proteins as specific binders to PACAP-38, a key mediator of migraine

This study designs mini-proteins that bind PACAP-38 with high affinity, showing improved potency and stability compared to earlier versions.

Structure of Bacillus cereus ZmaM, a peptidase-ABC transporter that secretes and activates zwittermicin A

The paper structures ZmaM, a type II peptidase-ABC transporter in B. cereus, showing it activates and exports zwittermicin A by coordinating peptidase and transporter modules.