A. B. Ward

This study maps polyclonal antibody responses in non-human primates vaccinated with HIV Env trimer subunit vaccines and identifies epitopes associated with neutralization breadth.

The paper identifies monoclonal antibodies from rabbits that bind an epitope overlapping the N332 glycan supersite but not the glycan hole, suggesting strain-specific responses may interfere with broadly neutralizing antibodies.

This study shows that immunization with B41 and BG505 SOSIP trimer immunogens in rabbits induces distinct autologous neutralizing antibody lineages targeting overlapping glycan hole epitopes, but broadening reactivity remains challenging.

The paper presents the 3.1 Å resolution structure of SARS-CoV NSP12 polymerase bound to NSP7 and NSP8 co-factors using cryo-EM, revealing its architecture and implications for antiviral drug design.

The paper presents a 3.1 Å cryo-EM structure of the Ebola virus nucleoprotein-RNA helical filament, providing detailed insights into protein-RNA and protein-protein interactions.

The paper reports cryo-EM structures of zebrafish Otop1 and chicken Otop3, revealing their dimeric architecture and potential proton conduction pathways.

This study compares native HIV-1 Env trimers with soluble SOSIP trimers, finding structural and antigenic similarities but differences in antibody binding and glycan composition.

The paper describes the structure of a chimpanzee SIV Env trimer and shows it induces HIV V2-specific neutralizing antibodies in mice.

This study shows that high serum neutralizing antibody titers from Env protein vaccination protect rhesus macaques from Tier 2 SHIV challenge, with ~1:500 ID50 titers providing over 90% protection.

The paper identifies a transiently exposed epitope on influenza H7 hemagglutinin that is targeted by a potent neutralizing monoclonal antibody.

This study shows that slow delivery immunization in rhesus macaques increases HIV-neutralizing antibody titers and germinal center responses by modulating immunodominance.

The paper presents the cryo-EM structure of the mechanically activated ion channel OSCA1.2 and supports its role in mechanosensation.

This paper demonstrates that gp41ECTO is the main source of HIV-1 envelope metastability and shows that stabilizing it improves nanoparticle assembly and induces more effective tier 2 neutralizing antibodies.

The paper presents a cryo-EM structure of Plasmodium falciparum CSP with vaccine-elicited antibodies, revealing a spiral conformation stabilized by inter-antibody contacts.

The paper reports the high-resolution cryo-EM structure of human SWELL1, revealing its trimer of dimers assembly and identifying a charged residue critical for pore function in VRAC.

This study uses cryo-EM to show that ACE2 binding and trypsin cleavage of SARS-CoV spike protein do not cause major conformational changes or expose the S2 cleavage site.