J. Stewart

BRCA1 secondary splice-site mutations drive exon-skipping and PARP inhibitor resistance

This study identifies secondary splice-site mutations in BRCA1 that drive exon skipping and PARP inhibitor resistance in ovarian and breast cancer.

Ronapreve (REGN-CoV; casirivimab and imdevimab) reduces the viral burden and alters the pulmonary response to the SARS-CoV 2 Delta variant (B.1.617.2) in K18-hACE2 mice using an experimental design reflective of a treatment use case

This study evaluates Ronapreve's efficacy against SARS-CoV-2 Delta and Omicron variants in mice, showing reduced viral burden and altered pulmonary response for Delta but not Omicron.

Most primary olfactory neurons have individually neutral effects on behavior

The paper investigates the behavioral effects of individual olfactory receptor neurons in Drosophila and finds that most have neutral effects, but their combinations can produce strong behavioral responses.

The prion and HSP104 modulate cytochrome c oxidase deficiency caused by deletion of COX12

The paper shows that deletion of COX12 in yeast leads to cytochrome c oxidase deficiency, which is mitigated by HSP104 and the loss of the [PSI+] prion.

FAM72A antagonizes UNG2 to promote mutagenic uracil repair during antibody maturation

This study identifies FAM72A as a regulator of mutagenic uracil repair during antibody maturation by antagonizing UNG2 activity.

Outdoor Atmospheric Microbial Diversity is Associated with Urban Landscape Structure and Differs from Indoor-Transit Systems as Revealed by Mobile Monitoring and Three-Dimensional Spatial Analysis

Using Drosophila behavioral assays to characterize terebrid venom-peptide bioactivity

This study uses Drosophila behavioral assays to assess the bioactivity of two terebrid venom peptides, finding distinct effects on pain and food intake.

Process proteomics of beer reveals a dynamic proteome with extensive modifications

This study uses mass spectrometry proteomics to analyze the dynamic proteome of beer production, identifying significant changes in protein abundance and modifications across process steps.

Neuromodulatory circuit effects on Drosophila feeding behaviour and metabolism

The paper investigates how silencing neuromodulatory systems in Drosophila affects feeding behaviour and metabolism by measuring multiple physiological and behavioural parameters.