Author

A. Desfosses

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:cryo-EM· 4 Research Focus:protein structure prediction· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:E. coli· 1 Assay:electronic health records· 1

Frequent Co-Authors

I. Gutsche· 2 shared M. Bacia-Verloop· 2 shared A. Burt· 1 shared A. K. Mitra· 1 shared A. Roux· 1 shared C. Boscheron· 1 shared C. K. Cassidy· 1 shared D. Chevret· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersMicrobiology

I. Gutsche

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

CryoEM architecture of a native stretch-sensitive membrane microdomain

J. M. Kefauver, M. Hakala, L. Zou, J. Alba, J. Espadas Moreno, M. G. Tettamanti, L. F. Estrozi, S. Vanni, A. Roux, A. Desfosses, R. Loewith

This study determines the cryo-EM structure of native yeast eisosomes, revealing lipid organization and dynamic stretching mechanisms in membrane microdomains.

bioRxiv · Aug 25, 2023Biophysics

Structural landscape of the Respiratory Syncytial Virus nucleocapsids

L. Gonnin, A. Desfosses, M. Bacia-Verloop, D. Chevret, M. Galloux, J.-F. Eleouet, I. Gutsche

This paper presents cryo-EM structures of RSV nucleocapsids, revealing their polymorphism and unique helical symmetry due to C-terminal N interactions.

bioRxiv · Feb 14, 2023Microbiology

Structural basis of CHMP2A-CHMP3 ESCRT-III polymer assembly and membrane cleavage

K. Azad, D. Guilligay, C. Boscheron, S. Maity, N. De Franceschi, G. Sulbaran, G. Effantin, H. Wang, J.-P. Kleman, P. Bassereau, G. Schoehn, W. Roos, A. Desfosses, W. Weissenhorn

This study presents cryo-EM structures of CHMP2A-CHMP3 ESCRT-III filaments and shows they constrict and cleave membrane tubes through electrostatic interactions and VPS4-mediated remodeling.

bioRxiv · Apr 12, 2022Cell Biology

Complete structure of the core signalling unit of the E. coli chemosensory array in an optimised minicell strain

A. Burt, C. K. Cassidy, P. Ames, M. Bacia-Verloop, M. Baulard, K. Huard, Z. Luthey-Schulten, A. Desfosses, P. J. Stansfeld, W. Margolin, J. S. Parkinson, I. Gutsche

The paper presents a 3D map of the E. coli chemosensory core signalling unit using cryo-ET and subtomogram averaging, combined with molecular dynamics simulations to create an atomistic model.

bioRxiv · Aug 5, 2019Cell Biology

In vitro assembly of the Rous Sarcoma Virus capsid protein into hexamer tubes under physiological conditions.

S. A. Jaballah, G. D. Bailey, A. Desfosses, J. Hyun, A. K. Mitra, R. L. Kingston

This study shows RSV CA assembles into hexamer tubes in vitro under physiological conditions, with spacer peptide influencing layering and tube structure.

Scientific Reports · Jun 6, 2017Peer-reviewedBiochemistry