D. R. Miller

The genomic and cellular basis of biosynthetic innovation in rove beetles

This study investigates the genomic and cellular basis of biosynthetic innovation in rove beetles, identifying key genomic and cellular mechanisms underlying the evolution of defensive secretions.

Multi-modal microvascular cerebral blood flow velocity mapping with 14T single-vessel MRI and optical microscopy in the mouse brain

This study combines 14T single-vessel MRI and optical microscopy to map cerebral blood flow velocity in mouse brain microvessels, validating measurements across modalities.

A Multitrait Locus Regulates Sarbecovirus Pathogenesis

The paper identifies a multitrait locus on mouse Chromosome 9 that regulates SARS-CoV, SARS-CoV-2, and bat sarbecovirus disease severity, with candidate genes CCR9 and CXCR6.

Common Mechanism of SARS-CoV and SARS-CoV-2 Pathogenesis across Species

The paper identifies host susceptibility loci for SARS-CoV and SARS-CoV-2 using GWAS and Collaborative Cross datasets, validating CCR9 as a key regulator of severe disease outcomes across species.

Baseline T cell immune phenotypes predict virologic and disease control upon SARS-CoV infection

The paper shows that baseline T cell immune signatures in mice predict virologic and disease outcomes upon SARS-CoV infection.

Establishing the Effect of Vascular Structure on Laser Speckle Contrast Imagining

The paper develops an ultrafast forward model to simulate laser speckle contrast images and demonstrates how vascular structure affects correlation decay times in mouse cerebral cortex.

Lgr5+ telocytes are a signaling hub at the intestinal villus tip

The paper identifies Lgr5+ telocytes at the intestinal villus tip as signaling hubs that regulate epithelial gene zonation through Bmp and Wnt5a signals.

Mechanism of manganese dysregulation of dopamine neuronal activity

This study investigates how manganese affects dopamine neuronal activity by altering calcium channel function and potassium channel recruitment, revealing a mechanism for manganese-induced neurological dysfunction.

In vivo multiphoton fluorescence imaging with polymer dots

This paper demonstrates the use of polymer dots for deep in vivo multiphoton imaging in mice, showing improved signal-to-background ratio and imaging depth.