A. Hernandez-Lain

The mechanoreceptor PIEZO1 is a novel oncogene in glioma by promoting astrocyte reactivity

This study identifies PIEZO1 as an oncogene in glioma that promotes astrocyte reactivity and is associated with worse prognosis in male patients.

A drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent local relapse and treat established brain metastasis

The paper introduces a drug-screening platform using organotypic cultures to identify effective treatments for brain metastasis, finding a potent HSP90 inhibitor that works against mouse and human metastases.

The genetic status of IDH1/2 and EGFR dictates the vascular landscape and the progression of gliomas

This study investigates how IDH1/2 and EGFR genetic mutations influence vascular characteristics and progression in gliomas, identifying distinct vascular phenotypes and therapeutic vulnerabilities.

Immune profiling of gliomas reveals a connection with Tau function and the tumor vasculature.

The paper profiles immune cells in gliomas, identifying two immune profiles in IDH1/2 wild-type tumors and linking immune content to vascular alterations and Tau expression.

IDH-Tau-EGFR triad defines the neovascular landscape of diffuse gliomas by controlling mesenchymal differentiation

This study identifies the IDH-Tau-EGFR triad as a key factor in defining the neovascular landscape of diffuse gliomas by regulating mesenchymal differentiation and vascular microenvironment.