Author

M. C. Wilkinson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

E. Crittenden· 3 shared N. R. Casewell· 3 shared R. A. Harrison· 3 shared C. A. Dawson· 2 shared J. Alsolaiss· 2 shared L.-O. Albulescu· 2 shared S. Ainsworth· 2 shared S. R. Hall· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersPharmacology & Toxicology

E. Crittenden

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Dermonecrosis caused by spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib

K. E. Bartlett, S. R. Hall, S. A. Rasmussen, E. Crittenden, C. A. Dawson, L.-O. Albulescu, W. M. Laprade, R. A. Harrison, A. J. Saviola, C. M. Modahl, T. P. Jenkins, M. C. Wilkinson, J. M. Gutierrez, N. R. Casewell

This study identifies toxin synergism in spitting cobra venom causing dermonecrosis and shows that varespladib prevents tissue damage in mouse models.

bioRxiv · Jul 20, 2023Pharmacology & Toxicology

Molecular simulations reveal a mechanism for enhanced allosteric coupling between voltage-sensor and pore domains in KCNQ1 explaining its activation by ML277

G. Kuenze, C. G. Vanoye, M. C. Wilkinson, R. R. Desai, S. Adusumilli, C. R. Sanders, A. L. George, J. Meiler

bioRxiv · May 31, 2022 · PreprintBiophysics

Exploring the utility of recombinantly expressed snake venom serine protease toxins as immunogens for generating experimental snakebite antivenoms

N. Alomran, P. Blundell, J. Alsolaiss, E. Crittenden, S. Ainsworth, C. A. Dawson, R. J. Edge, S. R. Hall, R. A. Harrison, M. C. Wilkinson, S. K. Menzies, N. R. Casewell

This study evaluates recombinant snake venom serine protease toxins as immunogens to generate antivenoms that target specific venom-induced pathologies.

bioRxiv · May 7, 2022 · PreprintImmunology

Preclinical validation of a repurposed metal chelator as a community-based therapeutic for hemotoxic snakebite

L.-O. Albulescu, M. Hale, S. Ainsworth, J. Alsolaiss, E. Crittenden, J. J. Calvete, M. C. Wilkinson, R. A. Harrison, J. Kool, N. R. Casewell

This paper shows that the metal chelator DMPS can effectively treat hemotoxic snakebite in mice, both when given orally and in combination with antivenom.

bioRxiv · Jul 28, 2019Pharmacology & Toxicology