T. C. Walther

PLD3 and PLD4 synthesize S,S-BMP, a key phospholipid enabling lipid degradation in lysosomes

This study identifies PLD3 and PLD4 as enzymes synthesizing S,S-BMP, a lysosomal phospholipid critical for lipid degradation and brain health.

The structure, catalytic mechanism, and inhibitor identification of phosphatidylinositol remodeling MBOAT7

This study determines the structure of MBOAT7, models its catalytic mechanism, and identifies potential inhibitors for therapeutic development.

Fitm2 is required for ER homeostasis and normal function of murine liver

This study shows that Fitm2 is essential for ER homeostasis and liver function in mice, with loss of Fitm2 causing ER stress and liver injury.

Mice lacking triglyceride synthesis enzymes in adipose tissue are resistant to diet-induced obesity

This study shows that mice lacking TG synthesis enzymes in adipose tissue are metabolically healthy and resistant to diet-induced obesity despite reduced TG storage.

Seipin transmembrane segments critically function in triglyceride nucleation and lipid droplet budding from the membrane

This study investigates how seipin's transmembrane segments contribute to triglyceride nucleation and lipid droplet budding using simulations and cell experiments.

Key Factors Governing Initial Stages of Lipid Droplet Formation

This study uses a coarse-grained model to investigate the biophysics of lipid droplet formation, showing that membrane rigidity and asymmetric tension influence TG nucleation and budding direction.

An open-access volume electron microscopy atlas of whole cells and tissues

The paper presents a 3D electron microscopy atlas of whole cells and tissues with high resolution and large volume, enabling new biological insights.

Progranulin deficiency results in reduced bis(monoacylglycero)phosphate (BMP) levels and gangliosidosis

This study shows that progranulin deficiency reduces bis(monoacylglycero)phosphate levels, leading to gangliosidosis and neurodegeneration.

Identification of two pathways mediating protein targeting from ER to lipid droplets

The paper identifies two distinct pathways for ER-to-LD protein targeting and characterizes the molecular machinery involved.

The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets

This study identifies spartin as a receptor mediating selective autophagy of lipid droplets and links its dysfunction to Troyer syndrome.

Conditional targeting of phosphatidylserine decarboxylase to lipid droplets

This study identifies a second form of phosphatidylserine decarboxylase, PISD-LD, which localizes to lipid droplets and is regulated by nutritional state, revealing its role in neutral lipid storage.

Lipid Droplets in Brown Adipose Tissue Are Dispensable for Cold-Induced Thermogenesis

This study shows that lipid droplets in brown adipose tissue are not required for cold-induced thermogenesis, as mice lacking triglyceride synthesis enzymes maintain thermogenic function through alternative fuel sources.

Lowe Syndrome-linked endocytic adaptors direct membrane cycling kinetics with OCRL in Dictyostelium discoideum.

This study identifies F&H peptide-containing proteins that interact with OCRL/Dd5P4 in Dictyostelium discoideum, revealing their role in endocytic membrane cycling and potential involvement in Lowe Syndrome phenotypes.