Author

Brendan Rooney

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Assay:scRNA-seq· 2 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Abdulraouf AbdulraoufiD· 1 shared Alison GoateiD· 1 shared Antti JunkkariiD· 1 shared Beth StevensiD· 1 shared Charles R. VanderburgiD· 1 shared Emmy LiiD· 1 shared Erik M. UllianiD· 1 shared Ethan S. LippmanniD· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperGenomics

Abdulraouf AbdulraoufORCID

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2 papers

Recent·Most cited

Early Alzheimer's disease pathology in human cortex is associated with a transient phase of distinct cell states

Vahid Gazestani, Tushar Kamath, Naeem M. Nadaf, S.J. Burris, Brendan Rooney, Antti Junkkari, Charles R. Vanderburg, Tuomas H. Rauramaa, Martine Therrien, Matthew Tegtmeyer, Sanna‐Kaisa Herukka, Abdulraouf Abdulraouf, Samuel E. Marsh, Tarja Malm, Mikko Hiltunen, , Evan Z. Macosko

The paper identifies a transient hyperactive neuronal state in early Alzheimer's disease using single-nucleus transcriptomics from living patients.

bioRxiv · Jun 3, 2023 · PreprintGenomics

CRISPRi screens in human astrocytes elucidate regulators of distinct inflammatory reactive states

Kun Leng, Indigo V.L. Rose, Hyosung Kim, Wenlong Xia, Wilber Romero‐Fernandez, Brendan Rooney, Mark Koontz, Emmy Li, Yan Ao, Shinong Wang, Mitchell C. Krawczyk, Julia TCW, Alison Goate, Ye Zhang, Erik M. Ullian, , Martin Kampmann

The paper uses CRISPRi screens and single-cell transcriptomics in human astrocytes to identify regulators of inflammatory reactive states and their relevance in disease.

bioRxiv · Aug 23, 2021 · PreprintNeuroscience