C. Huang

The paper investigates the PTEN:P-Rex2 complex, identifying how cancer mutations disrupt its inhibitory function and hyperactivate Rac1 signaling.

This study shows that the IMPDH inhibitor merimepodib suppresses SARS-CoV-2 replication in vitro by reducing viral titers by up to 4 logs after overnight pretreatment.

This study shows that Type I interferons significantly reduce SARS-CoV-2 viral titers in Vero cells, with IFN-β being more effective than IFN.

This study shows that glycyrrhizic acid improves cognitive function in aged mice by enhancing T and B cell proliferation and blood perfusion.

This study examines how Ursolic acid affects intestinal microbiota in liver fibrosis mice, finding improved microbial diversity and function in treated animals.

The paper introduces an efficient long fragment editing technique for scarless genome engineering in E. coli, enabling large-scale DNA insertion and deletion with high success rates.

This study shows that restricting essential amino acids, not non-essential ones, drives systemic metabolic responses to dietary protein dilution and genetic amino acid transport loss.

This study develops a reversed paired-gRNA plasmid cloning strategy to eliminate plasmid instability caused by direct repeats, achieving efficient genome editing in E. coli.

This study investigates the role of prolactin receptor signaling in beta-cell function during pregnancy, finding both cell-autonomous and non-cell-autonomous effects on glucose regulation and gene expression.

This study develops microscaled proteogenomic methods for cancer analysis, showing treatment response and resistance mechanisms in ERBB2-positive breast cancers.

The paper tests metagenomic sequencing with ONT MinION for strain-level identification of bacterial tomato pathogens, achieving success with Pto but showing challenges with field samples.

This paper demonstrates that CRISPR-Cas9-assisted native end-joining editing can efficiently knock out large genomic regions in E. coli without exogenous repair systems.

This paper develops a method to measure cell membrane micromechanics using fluorescence lifetime imaging of DiI, enabling analysis of lipid bilayer properties in situ.

This study shows that carbon monoxide dehydrogenases enhance bacterial survival by providing a supplemental energy source during organic carbon starvation.

This study shows that age-dependent protein aggregation in C. elegans forms amyloid-like structures and accelerates tissue functional decline, suggesting a role for protein aggregation in aging.

This study examines the sterilization effects of cavitation-shock interactions on marine Vibrio sp. through experimental and modeling approaches.

This study analyzes TCRB and IGH repertoires in IgAN patients to identify non-invasive biomarkers for diagnosis.