C. Li

This paper identifies and characterizes the gene PLATZ-A1 underlying the GA-sensitive dwarfing locus RHT25 in wheat, showing it interacts with RHT1 and can modulate plant height.

This study shows that peptide-poloxamine-DNA nanoparticles provide complete protection against lethal SARS-CoV-2 challenge through robust mucosal immunity.

This study identifies a regulatory axis involving acetylation and ubiquitination of Isw1 in Cryptococcus neoformans that controls multidrug resistance.

This paper introduces an antigen reorientation strategy using oligoD insertion to shift immune responses toward conserved epitopes, demonstrating improved cross-reactivity in influenza vaccines.

This study develops a deep learning model to classify hematopoietic stem cells and multipotent progenitors using light microscopy images, demonstrating its effectiveness in distinguishing functional subpopulations.

This study shows that shrimp STING detects DNA to trigger an interferon-like antiviral response, independent of cGAS and involving the IRF-Vago pathway.

The paper identifies a new CRISPR-Cas12l system from metagenomes, showing it cleaves DNA with a unique PAM and forms a bracelet structure for gene editing.

This study uses single-molecule imaging to show SUN2 dynamics and distribution on the nuclear envelope are regulated by actomyosin contractility and laminA/C network, affecting mechano-sensitive gene expression.

This study uses metabolomics to compare volatile metabolites across four Angelica species, identifying key compounds and phylogenetic correlations.

This study uses multiplex epigenome editing to reactivate MECP2 from the inactive X chromosome in RTT neurons, rescuing neuronal defects in vitro.

This paper shows that enhancer capture-divergence (ECD) is a significant evolutionary mechanism for asymmetric, distally duplicated genes, using Drosophila HP6/Umbrea as an example.

This study uses mid-infrared spectra of milk to establish models for assessing mammalian evolutionary relationships and genetic distances with high accuracy.

The paper introduces a gene co-expression analysis workflow in R that uses tidyverse and graph-based clustering to detect co-expressed gene modules.

This study shows that disrupting OsLAT5 in rice confers tolerance to dihydropyridine herbicides without affecting yield or grain quality.

This paper presents an optimized nuclei isolation protocol for diverse angiosperm species, yielding purified nuclei suitable for genomics experiments.

This study identifies SlG1 as a root-specific GGPP synthase that interacts with PSY3 to produce strigolactones in tomato roots, without affecting ABA or shoot development.

This study identifies PbE3-2, a protist effector that degrades RD21A to suppress plant immunity, contributing to clubroot disease.

This study identifies PhoP as a key regulator of pathogenicity in Riemerella anatipestifer by combining DAP-seq and transcriptome analysis, showing its role in aerotolerance and virulence.

SituSeq enables rapid, offline analysis of 16S rRNA gene amplicons using Nanopore MinION and a laptop, validated across platforms with high sequence identity and community composition consistency.

This study uses 16S rRNA gene sequencing to identify bacterial anomalies in deep-sea sediments linked to hydrocarbon seepage, finding distinct microbial signatures associated with thermogenic and biogenic hydrocarbons.

This paper develops and evaluates a flexible IrOx electrode for mouse vagus nerve stimulation, showing it remains functional under high stimulation and induces reliable physiological responses.

This study shows ELF3 regulates the light activation of PPD1 in wheat, affecting heading time through interactions with PHYB and PHYC.

The paper presents cryo-EM structures of bombesin receptors bound to their neuropeptide ligands, revealing the mechanism of ligand selectivity and receptor activation for itch treatment.

This study shows that inhibiting CHK2 reduces ZIKV production and rescues developmental defects by enhancing STING-dependent antiviral responses.

DeepAIR integrates sequence and 3D structure features of adaptive immune receptors to predict binding affinity and reactivity, outperforming existing methods on multiple tasks.

This study shows LKB1 suppresses JNK-dependent stress signaling in KRAS-mutant lung cancers, revealing a therapy-induced vulnerability that could improve KRAS-targeted therapies.

This study identifies dysregulated sphingolipid metabolism in TSC2-null cells and tumors, showing that ASAH1 inhibition reduces cell viability and tumor growth in TSC and LAM.

This study uses ancient DNA to trace tiger evolution, revealing China as a genetic melting pot and resolving taxonomic disputes among tiger subspecies.

This study identifies SAID1/2 as negative regulators of miRNA biogenesis in Arabidopsis by inhibiting the microprocessor complex through phase condensation and SE degradation.