C. Li

The paper identifies HLY72, a small-molecule derivative of lycorine, as an anti-obesity agent that targets Na+/K+-ATPase α3 in the brain, promoting lipolysis and thermogenesis without affecting food intake.

The paper evaluates the fitness effects of synonymous mutations in yeast, refuting claims that they are largely neutral and showing they are often deleterious.

This study identifies Zbtb20's role in regulating transcriptional and epigenetic programs during CD8 T cell differentiation and memory formation.

This study shows male T cells are more exhausted in glioblastoma, leading to worse outcomes and better response to anti-PD1 treatment compared to females.

The paper investigates NRF2's role in pulmonary artery endothelial and smooth muscle cells under hypoxia, finding differential regulation and effects on proliferation and migration.

The paper uses single-cell multi-omics to identify alkaloid biosynthesis genes in Catharanthus roseus, revealing gene clusters, paralogs, and cell-type specific expression patterns.

This study investigates how bio-oil components affect phenol-formaldehyde resin properties using model compounds, showing phenols and ketones improve synthesis while aldehydes and acids have negative effects, but all components enhance aging resistance.

This study identifies the optimal scanning speed and fiber-to-stone distance for maximizing dusting efficiency during Holmium: YAG laser lithotripsy by comparing photothermal ablation and cavitation effects.

This study shows that tumor-educated monocytes suppress T cells via adenosine and that depleting adenosine with PEG-ADA enhances immunotherapy response in preclinical models.

This paper describes a method to produce bulk cell-cultured fat tissue for food applications by aggregating adipocytes into 3D structures using binders, resulting in fat with similar texture and mechanical properties to animal fat.

TANKBind improves drug-protein binding structure prediction by incorporating trigonometry constraints and functional block segmentation, achieving better performance than existing methods.

MADET is a manually curated database that compiles 453 microbiota-drug associations from 24 papers to aid in understanding microbiota's role in anticancer drug efficacy and toxicity.

This study analyzes the adaptive immune landscape of T-cell mediated rejection in human kidney allografts using RNA sequencing and identifies key molecular features associated with rejection.

The paper identifies a new endolysosome process, LEA, where autophagosomes are engulfed by extending arms (LF) without fusion, and describes the molecular markers of engulfed autophagosomes.

This study investigates antibody evasion by SARS-CoV-2 Omicron sublineages BA.2.12.1, BA.4, and BA.5 against plasma from vaccination and BA.1 infection, showing increased neutralization escape.

This study shows metformin reduces Cyp26a1 expression, increasing atRA levels and decreasing pro-tumor CD8+ T cells, thereby preventing hepatocarcinogenesis in a mouse model.

This study describes an Early Triassic sauropterygian skeleton, identifies its phylogenetic position, and highlights the ancestral body plan and adaptive radiation of marine reptiles.

This paper reports the crystal structure of Rubella virus protease and demonstrates its protease and deubiquitylation activities, providing insights for antiviral drug development.

This study presents a chemomechanical model of sperm swimming that identifies two distinct modes of locomotion with different waveforms and velocity patterns based on dynein activity.

This paper identifies Coq1 as a target of a bisphosphonate that inhibits Toxoplasma gondii growth and protects mice from infection.

This study evaluates the consistency of ferret transmission experiments across laboratories for two H1N1 influenza viruses, finding concordant results and suggesting a minimum of three to five labs for reliable risk assessment.

This study examines how vaccination affects influenza A virus reassortment and genetic variation in pigs, finding reduced reassortant viruses in vaccinated pigs but no significant impact on genetic diversity.

The paper develops a multiplexed in vivo approach to identify driver genes in SCLC using CRISPR/Cas9 and lentiviral barcoding, finding TSC1 as a robust tumor suppressor.

The paper creates a 3-D cell type atlas of the monkey brain using single-cell spatial transcriptomics and identifies molecular markers for neocortical layers and subregions.

This study identifies TraB1 as a novel EMCS component in Arabidopsis that regulates both ER-mitochondrial tethering and mitophagy, essential for mitochondrial function and stress recovery.

This paper shows that Hinokitiol reduces fungal load and inflammation in Aspergillus fumigatus keratitis by altering gene expression and inhibiting fungal growth.

This study identifies OsIRO3 as a negative regulator of Fe homeostasis in rice by repressing OsIRO2, a positive regulator of Fe uptake.

This study shows that BA.2 causes stronger antibody evasion than BA.1, particularly in SARS convalescents, and identifies key mutations responsible for this escape.

This paper introduces a method to create autonomously regulated oxygen microenvironments in microscale cell cultures using an oil overlay, validated with simulations and experiments across multiple cell types.