C. Liu

This study links CD44-/CD24- breast cancer cells to late-stage tumor recurrence and identifies RHBDL2 as a regulator of CSC conversion.

The paper introduces a new protein labelling strategy called spot-tagging for use in plant cells, demonstrating its effectiveness with the Kinesin 7.3 protein.

This paper designs intrinsically disordered proteins with LCST phase behavior using Monte Carlo simulations and genetic algorithms.

This study shows that SARS-CoV-2 ORF3a induces incomplete autophagy by interacting with UVRAG, impairing autophagosome maturation and enhancing viral replication.

This study investigates the P710R mutation in β-cardiac myosin, showing it causes hypercontractility by disrupting the super-relaxed state, using multiscale experiments and modeling.

This study finds adolescents cooperate less than adults in social dilemmas due to lower intrinsic reward for reciprocity, not poor expectation of others' cooperation.

This study identifies synthetic lethality between ENDOD1 and TP53, showing that their combined loss causes DNA damage and cell death, suggesting ENDOD1 as a cancer therapeutic target.

The paper investigates the ftin gene's role in wheat under cold stress, finding it inhibits spike development through multiple pathways and phenotypic changes.

The paper develops a shrimp aquaculture ecosystem using predatory fish to control WSSV transmission, effectively preventing outbreaks.

This study identifies ceftazidime as a drug that inhibits SARS-CoV-2 infection by blocking the spike protein-ACE2 interaction in vitro, with an IC50 below therapeutic blood concentrations.

This study identifies mTOR S-nitrosylation as a kinase-independent mechanism that suppresses autophagy and lysosomal proteolysis, with implications for Alzheimer's disease.

This paper develops a deep learning system for gastric cancer detection using histopathological images, achieving high sensitivity and robust performance across different scanners.

This study examines polyploidization in Arabidopsis suecica, finding no genome shock but evidence of gradual adaptation through subgenome-specific gene upregulation.

This study shows that e-cigarette vapor causes mitochondrial DNA damage, which activates TLR9 and promotes atherosclerosis in mice.

The paper presents an improved guppy reference genome using long-read sequencing, revealing novel sex-linked regions and resolving previous contradictions in Y chromosome studies.

This paper develops a lentiviral vector for β-thalassemia treatment that restores β-globin expression in Chinese patients with minimal tumorigenesis risk.

This paper describes a catalase-based therapeutic for COVID-19 that reduces oxidative stress and cytokine production in human and animal models without toxicity.

This study shows luteolin alters BMDM polarization by modulating STAT1/6 pathways, reducing pro-inflammatory factors and increasing anti-inflammatory ones.

This study uses CRISPR/Cas9 and assODN to create an isogenic cell model of the HBB -28 (A>G) mutation and analyzes its transcriptome effects, revealing altered gene expression and pathway activation.

The paper uses RNA-seq and ATAC-seq to show that both SRMI and IRMI increase chromatin accessibility at defense genes, revealing overlapping transcriptional regulatory mechanisms.

This paper describes the development of an mRNA vaccine (mRNA-1273) against SARS-CoV-2, showing it induces neutralizing antibodies and CD8 T cell responses and protects mice from infection.

This study examines T cell immunity in UK COVID-19 patients, finding stronger and broader memory T cell responses in severe cases, with implications for vaccine design.

This study reports the largest sequenced plant genome, Paris polyphylla var. yunnanensis, and identifies genes involved in polyphyllin biosynthesis.

This study uses molecular dynamics simulations to show that a polysaccharide layer forms during desiccation, protecting the structure and function of Gram-negative bacterial outer membranes.

This paper develops a deep learning model to detect cancer regions and estimate PD-L1 tumor proportion scores in lung adenocarcinoma IHC slides, showing strong agreement with pathologists' interpretations.

This study identifies histone lysine crotonylation as an active promoter mark that regulates gene expression and neuronal differentiation in neural stem/progenitor cells.

This study uses intravital imaging to show that ERK promotes satellite cell migration during muscle regeneration by facilitating the G1/S transition and enhancing migration speed in the S/G2 phase through CDK2.

This study identifies APC mutations as a marker of aggressive BRAF mutant colorectal cancers, associated with poor prognosis and enhanced tumor growth in mouse models.

This study shows that ACE2-overexpressed mesenchymal stem cells improve cardiac function and reduce fibrosis in a rat myocardial infarction model.

DNA methyltransferase inhibitors enhance γδ T cell-mediated lung cancer killing by remodeling immune synaptic cytoskeletal networks.