C. Wu

This study investigates HMGB1's role in invasive C. albicans infection and shows that EP reduces HMGB1 levels, tissue damage, and mortality in infected mice.

This study shows that RIP1 kinase activity in macrophages drives steatohepatitis by promoting cell death and inflammation, and its inhibition reduces liver injury in NASH models.

This study shows that replacing amino acids 11 and 12 in mouse angiotensinogen with human counterparts does not affect renin cleavage or angiotensin II-mediated functions in mice.

This study identifies CDK13 mutations in melanoma, showing they lead to accumulation of truncated transcripts and poor survival, with a mechanism involving impaired ZC3H14 phosphorylation and PAXT complex recruitment.

This study shows LIMD1 phase separation at focal adhesions regulates force sensing and durotaxis by controlling FA dynamics in response to mechanical cues.

This paper shows that increasing cryo-EM sample freezing temperature reduces beam-induced motion and improves reconstruction resolution by including more undamaged initial frames.

This study identifies TIGAR as a driver of metabolic remodeling in ESCC, showing that targeting the glutamine pathway improves therapeutic outcomes in TIGAR-overexpressed tumors.

This study maps host-parasite-microbiome interactions in Chagas disease, identifying metabolic factors that influence tissue tropism and disease tolerance.

This study shows STING activates the NLRP3 inflammasome by recruiting NLRP3 to the ER and deubiquitinating it, enhancing IL-1β secretion and inflammatory responses.

This study develops a rectal cancer organoid model that mimics patient tumor responses to chemoradiation and metastasis in mice.

This study shows gut-innervating nociceptors protect against Salmonella typhimurium infection by modulating microbiota and Peyer’s patch microfold cells.

This study identifies novel glycerolated quinazolinones produced by Streptomyces sp. MBT27 under glycerol-induced conditions and elucidates their biosynthetic pathway.

This study identifies Lsm12 as a regulator that mediates Polη deubiquitination to enhance its recruitment and improve survival under oxidative stress in yeast.

The paper identifies the SUMO-Ubiquitin-Cdc48 pathway as a negative regulator of RNA polymerase III in budding yeast, leading to proteasomal degradation of Pol III subunits and repression of transcription.

This study shows that angular compounding in optical coherence tomography reduces speckle but with limited signal-to-noise ratio improvement due to optical aberrations and resolution trade-offs.