C. Wu

The paper develops and characterizes monospecific and bispecific monoclonal antibodies that neutralize SARS-CoV-2 and its variants, including B.1.617.2 Delta.

This study shows that nicotinamide riboside (NR) improves mitochondrial function and reduces inflammation in diabetic kidney disease by enhancing NAD metabolism and inhibiting the cGAS-STING pathway.

This study identifies how viral RNA interacts with coat proteins to sense host environments and trigger capsid disassembly in Turnip crinkle virus.

This study shows Ste50p localizes to polarity sites during yeast shmoo formation and correlates with cell-fate decisions in response to pheromone.

The paper uses single-molecule FRET to show SWR1 unwraps DNA and exchanges H2A-H2B for H2A.Z-H2B with timed precision.

This study identifies PLATZ4's role in enhancing drought tolerance and ABA sensitivity in Arabidopsis by suppressing PIP2;8 and upregulating stress-related genes through interaction with AITR6.

Single-cell analysis of human hematopoiesis uncovers the stage at which FcεRI appears during mast cell differentiation and reveals disparate effects of IL-3, IL-5 and IL-33 on mast cell progenitor proliferation, survival, and suppression of FcεRI expression.

This study shows that fascin promotes lung cancer growth and metastasis by enhancing glycolysis through YAP1-PFKFB3 activation.

This study identifies Prevotella histicola as a protective agent against estrogen-deficiency induced bone loss via the gut microbiota-bone axis in mice.

This study examines how Salmonella develops resistance to enrofloxacin under varying sub-inhibitory concentrations, identifying gene expression changes and mutations involved in resistance.

This paper identifies the molecular mechanism of Jin Ning Fang's anti-lung cancer effect using network pharmacology and experimental validation, revealing key targets and compounds involved.

This study uses single-cell transcriptomics to identify novel cell populations and functional differences in human nucleus pulposus during degeneration, revealing potential regenerative and immunosuppressive roles.

This study identifies SiAUX1 as critical for lateral root development in Setaria italica, revealing its role in cell volume distribution and vascular strand formation through mutant analysis and RNAseq.

ZF2001, a tandem-repeat dimeric RBD protein vaccine, induces strong immune responses and protects mice and non-human primates from SARS-CoV-2 infection.

The paper analyzes metagenomic data from microbial communities to identify strategies underlying xenobiotic degradation and their ecological interactions.

This study identifies SiCEP3, a C-terminally encoded peptide from Setaria italica, which promotes ABA import and signaling by inhibiting receptor kinase activity under abiotic stress.

The paper identifies distinct neural circuits regulating AVP neuron activity during drinking and eating, revealing presystemic regulation mechanisms for osmolality anticipation.

This paper constructs and analyzes metabolic models of Drosophila gut microbiota under different nutrient regimes to reveal dynamic metabolic interactions and their impact on host physiology.

This study characterizes the SARS-CoV-2 N protein, identifying domain-specific functions and highlighting the C-terminal domain's immunogenicity for diagnostic applications.

This paper describes a protocol for inducing collagen-induced arthritis (CIA) in mice using bovine collagen type II and Freund's adjuvants, and reports associated enteritis and arthritis outcomes.

The paper evaluates methods to enhance skin permeation of decapeptide-12, finding that microneedle patches with palmitate-modified peptides provide the best delivery.

This paper develops a semi-supervised deep learning model for colorectal cancer recognition using pathological images, showing it outperforms supervised learning with limited labeled data and matches pathologists' performance.

The paper analyzes proteome and phosphoproteome changes in EGFR TKI-resistant lung cancer cells to identify drug targets that can overcome resistance.

This paper creates a single-cell transcriptomic atlas of the Chinese horseshoe bat to study its role as a viral reservoir, identifying cell types and receptor expression patterns related to viral entry.

This study identifies integrin activation and apoptosis as the mechanism of rapid platelet clearance after cold storage and shows that EGTA treatment enables cold storage of platelets for transfusion.

The paper shows extracellular histones cause disseminated intravascular coagulation (DIC) via tissue factor-dependent lytic cell death, independent of inflammasome or TLR pathways.

This study shows that culturing murine BMSCs under hypoxia reduces hematopoietic contamination and increases stromal cell population.

This study identifies Paxillin's role in promoting ATP-induced activation of P2X7 receptor and NLRP3 inflammasome through complex formation and deubiquitination.

This paper reprograms the endogenous CRISPR-Cas10 system in Mycobacterium tuberculosis for efficient gene editing, RNA interference, and genome-wide screening, enabling functional genomics studies and drug/vaccine development.

The paper quantifies vertebrate biodiversity in Ailaoshan reserve using leech iDNA, showing species richness increases with elevation and distance from the reserve edge.