D. H. O'Connor

This study shows that potent antibody-dependent cellular cytotoxicity (ADCC) by a V2-specific antibody is insufficient to protect macaques against SIV challenge, but reduced viral loads were observed with a neutralization-sensitive SIV variant.

This study shows that African-lineage ZIKV infection in early first trimester causes high pregnancy loss in rhesus macaques, regardless of SIV status.

A new HAV genotype causing transient liver enzyme elevations in macaques was identified using deep sequencing, and vaccination prevented recurrence.

This paper assesses gait development in infant rhesus macaques using the Noldus Catwalk system, finding that diagonal walking patterns emerge early and gait parameters show limited change over the first month.

This study shows that high-dose African-lineage Zika virus infection in late first trimester pregnant rhesus macaques causes frequent fetal loss.

This study shows that a tyrosine-based trafficking signal in SIV Env is strongly selected for during pathogenic infection, as mutations reconstitute endocytosis and polarized sorting signals.

This study infects pregnant rhesus macaques with African- and Asian-lineage Zika virus to compare their pathogenesis, finding similar replication kinetics but higher viral burden in maternal-fetal interface tissues with African-lineage isolates.

This study identifies B cell epitopes across the SARS-CoV-2 proteome using peptide microarrays, showing antibody reactivity to multiple viral proteins and correlations with illness severity.

This study uses CT and PET/CT imaging to quantify SARS-CoV-2-induced lung abnormalities in crab-eating macaques, providing an objective endpoint for evaluating medical countermeasures.

This study analyzes SARS-CoV-2 within-host diversity using metagenomic sequencing and finds low genetic variation with limited evidence of positive selection in clinical and cell culture samples.

This paper uses an ultradense peptide array to identify MHC class I binding peptides, finding 64% of known epitopes and three novel ones in rhesus macaques.

This study shows that rhesus macaques retain neutralizing antibodies against ZIKV for at least 27 months, protecting them from detectable plasma viremia upon rechallenge.

This study introduces a method to genotype MHC class I and II from rhesus macaque exome sequences with high accuracy, outperforming conventional methods.

This study investigates whether prior dengue or Zika virus infection affects the severity of subsequent heterologous secondary infections in macaques, finding no significant impact on clinical outcomes.

This paper compares host responses to SHFV infection in patas and rhesus monkeys, identifying overlapping and species-specific cytokine and immune cell changes that may drive hemorrhagic fever pathogenesis.

This study infects olive baboons and rhesus macaques with SWBV-1, a simartevirus, and finds no disease in either species despite high viral replication and immune responses.

This study profiles anti-ZIKV antibody reactivity in macaques and shows that ZIKV-specific responses can wane over time and may be confused with DENV cross-reactivity.

This paper uses molecularly barcoded Zika virus to study in vivo infection dynamics in pregnant and non-pregnant macaques and mosquitoes, finding stable lineage proportions during acute infection but a rapid decline in complexity post-infection in pregnant animals.

This study reports ocular and uteroplacental pathology in rhesus macaques infected with ZIKV during pregnancy, showing prolonged viral replication and severe fetal outcomes.

This study infects pregnant rhesus macaques with ZIKV and observes prolonged maternal viremia and fetal tissue infection, indicating efficient vertical transmission.

This study assesses the risk of Zika virus transmission through mucosal contact in rhesus macaques, finding that oral secretions from infected individuals pose a low transmission risk.