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Primary ORCID profile (0000-0001-5381-1745 · 2 papers)Unclaimed ORCID profile · follow to get notified of new preprints
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38 papers
Recent·Most cited
J. A. Bernatchez, E. Chen, M. V. Hull, C. W. McNamara, J. H. McKerrow, J. L. Siqueira-Neto
The paper screens 12,000 compounds from the ReFRAME library against Trypanosoma cruzi, identifying 7 with potent in vitro activity and therapeutic index ≥10.
bioRxiv · Dec 11, 2019Microbiology
T. Pham, K. Robinson, T. Vleeshouwer-Neumann, J. Annis, E. Chen
This study identifies GRK5 as a novel regulator of rhabdomyosarcoma growth and self-renewal, showing its kinase-independent role in promoting tumor progression and suggesting it as a therapeutic target.
bioRxiv · Nov 12, 2019Cancer Biology
E. Chen, T. Q. Pham, K. Robinson, L. Xu, S. X. Skapek
This study identifies HDAC6 as a driver of RMS tumor growth, self-renewal, and migration/invasion, with RAC1 as a key mediator, suggesting targeting the HDAC6-RAC1 axis as a therapeutic strategy.
bioRxiv · Oct 30, 2019 · PreprintCancer Biology
S. A. Banse, M. Lucanic, C. A. Sedore, A. L. Coleman-Hulbert, W. T. Plummer, E. Chen, J. L. Kish, D. Hall, B. Onken, M. P. Presley, E. G. Jones, B. W. Blue, T. Garrett, M. Abbott, J. Xue, , P. C. Phillips
The paper compares manual and automated lifespan assays in Caenorhabditis strains, finding that automated methods reproduce results but show assay-specific effects of chemical interventions.
bioRxiv · Sep 14, 2019Physiology
M. Garnett, G. Picco, E. Chen, L. Garcia Alonso, F. Behan, E. Goncalves, G. Bignell, A. Matchan, B. Fu, R. Banerjee, E. Anderson, A. Butler, C. Benes, U. McDermott, D. Dow, , J. Saez-Rodriguez
The paper functionally links gene fusions to cancer cell fitness using drug sensitivity and CRISPR-Cas9 data, identifying rare functional fusions and novel therapeutic targets.
bioRxiv · Feb 24, 2019Cancer Biology
G. Balmus, D. Pilger, J. Coates, M. Demir, M. Sczaniecka-Clift, A. Barros, M. Woods, B. Fu, F. Yang, E. Chen, M. Ostermaier, T. Stankovic, H. Ponstingl, M. Herzog, K. Yusa, , S. P. P. Jackson
The paper identifies how ATM counteracts toxic non-homologous end-joining at broken replication forks by showing that loss of NHEJ components or BRCA1-A complex confers resistance to DNA-damaging agents in ATM-deficient cells.
bioRxiv · May 24, 2018Cell Biology
A. Yiu, K. Christensen, J. M. Arlt, E. Chen
The paper compares distress tolerance across self-report, behavioral, and psychophysiological domains in women with eating disorders and healthy controls, finding higher negative emotions in eating disorder groups.
bioRxiv · Mar 10, 2018Physiology
T. Cokelaer, E. Chen, F. Iorio, M. P. Menden, H. Lightfoot, J. Saez-Rodriguez, G. J. Mathew
GDSCTools provides a software package for analyzing pharmacogenomic data to identify genomic markers of drug response in cancer.
bioRxiv · Jul 28, 2017Cancer Biology