Author

J. A. Shavit

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 2 Bioengineering· 1 Evolutionary Biology· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:zebrafish· 4 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Organism:mouse· 1 Assay:protein sequence· 1

Frequent Co-Authors

D. Ginsburg· 2 shared A. Bernard· 1 shared A. C. Ferguson· 1 shared A. C. Weyand· 1 shared A. Nesvizhskii· 1 shared A. Yee· 1 shared A.-C. Gingras· 1 shared B. McGee· 1 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersPathology

D. Ginsburg

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Author profile →

6 papers

Recent·Most cited

Magnetically Powered Microwheel Thrombolysis of Occlusive Thrombi in Zebrafish

M. H. H. Pontius, C.-J. Ku, M. J. Osmond, D. Disharoon, Y. Liu, D. W. M. Marr, K. B. Neeves, J. A. Shavit

This paper demonstrates that tPA-functionalized microwheels, guided by magnetic fields, can efficiently dissolve occlusive thrombi in zebrafish larvae, outperforming systemic tPA delivery.

bioRxiv · Sep 11, 2023Bioengineering

Nuclear Progestin Receptor Mediated Linkage of Blood Coagulation and Ovulation

J. Huang, S. Chao, D. Liu, N. Zhao, J. A. Shavit, Y. Zhu, S. Chen

This study shows that progestin receptors regulate coagulation factors during ovulation in zebrafish, linking blood clotting to the ovulation process.

bioRxiv · Nov 8, 2021Physiology

Acitretin mitigates uroporphyrin-induced bone defects in congenital erythropoietic porphyria models

J. Bragazzi Cunha, J. S. Elenbaas, D. Maitra, N. Kuo, R. Azuero-Dajud, A. C. Ferguson, M. S. Griffin, S. I. Lentz, J. A. Shavit, B. Omary

This study identifies acitretin as a potential treatment for congenital erythropoietic porphyria by mitigating uroporphyrin-induced bone defects in a zebrafish model.

bioRxiv · Mar 30, 2021Pathology

Phage Display Broadly Identifies Inhibitor-reactive Regions in von Willebrand Factor

A. Yee, M. Dai, S. E. Croteau, J. A. Shavit, S. W. Pipe, F. Meng, D. Ginsburg

This study uses phage display and NGS to identify inhibitor-reactive regions in von Willebrand factor, revealing distinct patterns among patients and overlap with a commercial antibody.

bioRxiv · Mar 8, 2021Pathology

Thrombocyte inhibition restores protective immunity to mycobacterial infection

E. Hortle, K. E. Johnson, M. D. Johansen, T. Nguyen, J. A. Shavit, W. J. Britton, D. M. Tobin, S. H. Oehlers

This study shows that inhibiting thrombocyte activation improves control of mycobacterial infection by reducing thrombocyte-macrophage interactions and restoring macrophage immunity.

bioRxiv · Dec 1, 2018Immunology

The Function of the COPII Gene Paralogs SEC23A and SEC23B Are Interchangeable In Vivo

R. Khoriaty, G. Hesketh, A. Bernard, A. C. Weyand, D. Mellacheruvu, G. Zhu, M. J. Hoenerhoff, B. McGee, L. Everett, E. J. Adams, B. Zhang, T. Saunders, A. Nesvizhskii, D. J. Klionsky, J. A. Shavit, , D. Ginsburg

This study shows SEC23A and SEC23B are functionally interchangeable in vivo, suggesting phenotypic differences arise from gene expression rather than protein function.

bioRxiv · Nov 7, 2017Evolutionary Biology