K. De Paris

Germline-targeting SOSIP trimer immunization elicits precursor CD4 binding-site targeting broadly neutralizing antibodies in infant macaques.

This study shows that a multi-dose immunization with germline-targeting SOSIP vaccines induces precursor broadly neutralizing antibodies in infant macaques, similar to adult responses.

High-risk microbial signatures are associated with severe parasitemia in controlled Plasmodium infections of both humans and rhesus macaques

The paper identifies a high-risk microbial signature in the gut microbiome associated with severe parasitemia in both humans and rhesus macaques during controlled Plasmodium infections.

Vaccine-induced, high magnitude HIV Env-specific antibodies with Fc-mediated effector functions are insufficient to protect infant rhesus macaques against oral SHIV infection

This study tests a vaccine regimen in infant rhesus macaques, finding that Env-specific antibodies with Fc effector functions do not prevent oral SHIV infection.

Different adjuvanted pediatric HIV envelope vaccines induced distinct plasma antibody responses despite similar B cell receptor repertoires in infant rhesus macaques.

SARS-CoV-2 Vaccines Elicit Durable Immune Responses in Infant Rhesus Macaques

This study evaluates two SARS-CoV-2 vaccines in infant rhesus macaques, finding both induce durable antibody and T cell responses without adverse effects.

Analytical treatment interruption after short-term anti-retroviral therapy in a postnatally SHIV infected infant rhesus macaque model

This paper develops an infant rhesus macaque model of SHIV infection and analytical treatment interruption to study viral rebound and identify biomarkers for pediatric HIV functional cure strategies.

Signatures of divergent antimalarial treatment responses in peripheral blood from infants and adults in Malawi

This study identifies age-specific immune and parasitic response signatures in infants and adults with malaria in Malawi following antimalarial treatment.

Oral clade C SHIV challenge models to study pediatric HIV-1 infection by breastmilk transmission

This paper evaluates three clade C SHIVs for oral transmission and infection in infant rhesus macaques, finding varied chronic viremia levels and seroconversion thresholds.

SHIV.CH505-infected infant and adult rhesus macaques exhibit similar HIV Env-specific antibody kinetics, despite distinct T-follicular helper (Tfh) and germinal center B cell landscapes

This study compares HIV-specific antibody kinetics in infant and adult rhesus macaques infected with SHIV, finding similar antibody responses despite differences in Tfh and germinal center B cell dynamics.