Author

G. M. Wahl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Y.-C. Li· 2 shared A. Iuga· 1 shared A. Ma· 1 shared A. Malik· 1 shared A. R. Decker· 1 shared B. R. Stockwell· 1 shared C. A. Lyssiotis· 1 shared C. E. M. Firl· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersCancer Biology

Y.-C. Li

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Author profile →

4 papers

Recent·Most cited

RAF conformational autoinhibition and 14-3-3 proteins promote paradoxical activation

G. Mendiratta, K. Abbott, Y.-C. Li, J. Yu, J. Huang, M. N. Shokhirev, T. McFall, G. M. Wahl, E. C. Stites

The paper investigates paradoxical activation of RAF kinases, showing that 14-3-3 proteins enhance this effect by stabilizing RAF conformations and dimerization.

bioRxiv · Oct 29, 2021Cancer Biology

Loss of epigenetic regulation disrupts lineage integrity, reactivatesmultipotency and promotes breast cancer

E. Langille, K. N. Al-Zahrani, Z. Ma, A. Malik, S. K. Loganathan, D. Trcka, J. Liu, K. Kozma, R. Tsai, K. Teng, R. Espin, S. Barutcu, T. Nguyen, R. Bremner, H. W. Jackson, , D. Schramek

This study identifies epigenetic regulators as tumor suppressors in breast cancer by showing their loss leads to lineage infidelity and reactivation of lactation programs.

bioRxiv · Oct 22, 2021 · PreprintCancer Biology

Induction of pancreatic tumor-selective ferroptosis through modulation of cystine import

M. A. Badgley, D. Kremer, H. C. Maurer, K. E. DelGiorno, H.-J. Lee, V. Purohit, I. Sagalovskiy, A. Ma, J. Kapillian, C. E. M. Firl, A. R. Decker, S. A. Sastra, C. F. Palermo, L. R. Andrade, P. Sajjakulnukit, , K. P. Olive

The paper shows that targeting cystine import induces ferroptosis in pancreatic tumors, leading to tumor regression and improved survival in a mouse model.

bioRxiv · Nov 1, 2019 · PreprintCancer Biology

Facile real time detection of membrane colocalization of RAS superfamily GTPase proteins in living cells

Y.-C. Li, L. Wang, T. K. Hayes, M. N. Sutton, R. C. Bast, F. McCormick, C. J. Der, G. M. Wahl

This study uses ReBiL2.0 to show that the C-terminal HVR-CAAX domain directs KRAS to colocalize with other prenylated proteins, impacting its signaling.

bioRxiv · Jul 15, 2018Cancer Biology