G. Tellides

Heterogeneous Cardiac- and Neural Crest-Derived Aortic Smooth Muscle Cells have Similar Transcriptional Changes after TGFβ Signaling Disruption

The paper analyzes single-cell transcriptomes of aortic smooth muscle cells in mice to show distinct origins and similar transcriptional changes after TGFβ signaling disruption.

Short-Term Disruption of TGFβ Signaling in Adult Mice Renders the Aorta Vulnerable to Hypertension-Induced Dissection

This study shows that disrupting TGFβ signaling in adult mice makes the aorta susceptible to hypertension-induced dissection, even from short-term blood pressure increases.

Smooth Muscle Cell Death Drives an Osteochondrogenic Phenotype and Severe Proximal Vascular Disease in Progeria

This study links smooth muscle cell death to osteochondrogenic changes and vascular disease in progeria, identifying a sequence of pathological events leading to cardiovascular complications.

Fibronectin-integrin α5 signaling promotes thoracic aortic aneurysm in a mouse model of Marfan syndrome

This study shows that fibronectin-integrin α5 signaling drives thoracic aortic aneurysms in Marfan syndrome mice, with a 5/2 chimera mutation reducing aneurysm severity.

Lonafarnib improves cardiovascular function and survival in a mouse model of Hutchinson-Gilford Progeria Syndrome

Lonafarnib improves cardiovascular function and survival in a progeria mouse model by reducing pulse wave velocity and enhancing left ventricular diastolic function.

Genetic Background Dictates Aortic Fibrosis in Hypertensive Mice

This study shows that genetic background strain influences aortic fibrosis in hypertensive mice, with C57BL/6J mice showing more maladaptive remodeling than 129SvEv mice.