H. Lu

This paper develops a LAMP-based microfluidic chip for rapid, portable detection of Cryptococcus in CM, enabling visual, sample-to-answer diagnosis without additional instruments.

This study shows neonicotinoids increase methane emission in Periplaneta americana by altering gut bacteria to produce more hydrogen, which methanogens use to generate methane.

The paper identifies a long-lasting salt bridge as the key mechanism anchoring oncogenic KRas-4B to cell membranes through all-atom simulations.

The paper identifies genetic signatures for classifying HPV16, 18, 52, and 58 variants into lineages/sublineages with high accuracy using publicly available genomes.

This study shows that coronatine, a bacterial toxin, more effectively regulates the Arabidopsis circadian clock than plant-derived jasmonates.

The paper screens SARS-CoV-2 target cells across 11 animal species using single-cell transcriptomes, finding higher proportions in cats and detecting them in multiple pig cell types.

This study identifies ARTS as a p53-responsive gene that promotes mitochondrial apoptosis by interacting with p53 and enhancing its pro-apoptotic effects.

This study creates a single-cell transcriptome atlas of a non-human primate to explore SARS-CoV-2 targets and immune responses, identifying potential therapeutic targets and mechanisms linking IL6 to viral entry.

This study investigates the beampattern generated by resonance cavities in the Brown Long-Eared Bat and supports the hypothesis that frequency-driven sidelobe scanning arises from resonance in split cavities.

This study creates a zebrafish model expressing Abcb4 to investigate drug resistance mechanisms, finding that NF-κB plays a central role in regulating Abcb4-mediated resistance.

The paper identifies and validates five plasma metabolite biomarkers for precise pancreatic cancer diagnosis and progression monitoring using metabolomics.

This study identifies five functional metabolites regulated by iron via siderophore-dependent pathways that directly influence biofilm formation.

This study develops an artificial sonar system inspired by the brown long-eared bat's vertical sound localization, showing that binaural conformation and orientation are critical for spatial target localization.

This study examines microbiome changes in lung and gut of NSCLC patients and finds sputum microbiota better predicts disease and metastasis than gut microbiota, with machine learning models achieving 0.842 AUC.

The paper introduces HeALTH, an automated microfluidic system for longitudinal behavioral studies of C. elegans under precise environmental control, demonstrating its utility in aging research and beyond.

The paper presents a large multi-omic cohort of 2,183 adults to identify correlations between gut microbiome features and various health-related factors, validated in an additional cohort.

This study identifies that long GlcNAc polysaccharides stabilize poliovirus by bridging viral capsid proteins, while short oligosaccharides only bind without enhancing stability.

This study shows that NKT cells from HIV-1 infected patients can be expanded and produce antiviral cytokines when stimulated with ex vivo dendritic cells loaded with alpha-galactosylceramide, except in advanced AIDS patients.

This study maps the single-cell transcriptome and surface antigens of ovarian cortex cells, revealing six main cell types and showing DDX4 captures perivascular cells, not oogonial stem cells, supporting a limited ovarian reserve.

The paper analyzes ancient DNA from museum specimens to show that Southern Chinese gray wolves form a distinct sub-population with genetic links to an extinct canid related to dholes.

This paper introduces a new transcranial magnetic stimulator coil design that improves depth-focality tradeoff and allows adjustable focal spot size for deep brain stimulation.

This study analyzes the vagino-cervical microbiome of 516 women using metagenomic shotgun sequencing to explore how pregnancy, delivery, and contraception influence microbiome composition.

This study shows that loss of SHMT2 promotes 5-FU resistance in CRC by inducing autophagy through p53 regulation.

This study shows APOC2 promotes colorectal cancer by altering lipid metabolism and activating PHF8 transcription, linking it to poor prognosis.

The paper uses metabolomics to identify metabolic changes required for biofilm formation in Uropathogenic Escherichia coli.

This study shows TAZ uses phase separation to compartmentalize transcription factors and enhance gene expression, distinct from its paralog YAP.

This study shows that Hmgcr downregulation in response to Influenza A infection occurs independently of the IFN pathway in human cells.

This study identifies PD-1 palmitoylation, its regulatory enzyme, and develops a peptide inhibitor to target PD-1 expression for cancer immunotherapy.

The paper identifies a beneficial genomic rearrangement in C. elegans that creates multiple versions of the rcan-1 gene, enhancing fitness and exploration behavior.