H. Lu

Universal chimeric Fcγ receptor T cells with appropriate affinity for IgG1 antibody exhibit optimal antitumor efficacy

This study evaluates the impact of Fcγ receptor affinity on CAR T cell efficacy and safety, finding that moderate affinity provides optimal antitumor activity while high affinity causes toxicity.

Born with intronless ERF transcriptional factors: C4 photosynthesis inherits a legacy dating back 450 million years

This study identifies intronless ERF transcription factors as a molecular tool used in the evolution of C4 photosynthesis in multiple plant lineages.

Tumor microenvironments impair T cell receptor affinity and function

This study shows that CD8+ T cells in the tumor microenvironment have reduced TCR-pMHC affinity and function, impairing their anti-tumor activity.

A Mechanistic Study on the Cellular Uptake, Intracellular Trafficking, and Antisense Gene Regulation of Bottlebrush Polymer-Conjugated Oligonucleotides

This paper investigates the cellular uptake, trafficking, and antisense gene regulation mechanisms of bottlebrush polymer-conjugated oligonucleotides in cancer cells.

Sex differences in the nasal microbiome of healthy young adults

This study analyzes the nasal microbiome of healthy young adults, revealing sex-specific differences in composition and ecological stability between males and females.

Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball patterned arrays

This study develops Stereo-seq, a high-resolution spatial transcriptomic method, to analyze mouse organogenesis and map developmental disease loci.

Cell transcriptomic atlas of the non-human primate Macaca fascicularis

The paper presents a single-cell transcriptomic atlas of Macaca fascicularis, identifying cell interactions and disease associations.

MRSCloud: a Cloud-based MR Spectroscopy Tool for Basis Set Simulation

MRSCloud is a cloud-based tool for simulating MR spectroscopy basis sets, achieving high accuracy and reduced runtime compared to existing methods.

A novel anti-PD-L1/IL-15 immunocytokine overcomes resistance to PD-L1 blockade and elicits potent antitumor immunity

This study develops an immunocytokine (LH01) combining anti-PD-L1 and IL-15 to enhance antitumor immunity and overcome resistance to PD-L1 blockade in mouse models.

ASGR1 is a candidate receptor for SARS-CoV-2 that promotes infection of liver cells

The paper identifies ASGR1 as a potential receptor for SARS-CoV-2 that facilitates liver cell infection and suggests soluble ASGR1 as a therapeutic target.

HMGN5 escorts oncogenic STAT3 signaling by regulating chromatin landscape in tumorigenesis of breast cancer

This study identifies HMGN5 as a novel epigenetic target in breast cancer by showing it promotes tumorigenesis through STAT3-mediated chromatin regulation and suggests siRNA-based therapy.

Single-nucleus RNA Sequencing and Spatial Transcriptomics Reveal the Immunological Microenvironment of Cervical Squamous Cell Carcinoma

This study uses snRNA-seq and Stereo-seq to analyze the immunological microenvironment of cervical squamous cell carcinoma, identifying immune cell clusters and their associations with tumor progression and patient survival.

Histone demethylase UTX regulates glioblastoma progression through affecting periostin expression

This study shows that UTX promotes glioblastoma progression by upregulating periostin expression, and its knockdown inhibits tumor growth and promotes apoptosis.

Deep learning redesign of PETase for practical PET degrading applications

This paper uses deep learning to redesign PETase, creating a highly active and stable enzyme for efficient PET degradation and industrial recycling.

An intein-mediated split-nCas9 system for base editing in plants

This paper develops a split-nCas9 system using intein-mediated reassembly for efficient base editing in plants.

Plant-based biosensors for detecting CRISPR-mediated genome engineering

This study develops plant-based biosensors to detect CRISPR/Cas tools in real-time, demonstrating their effectiveness in detecting various CRISPR functions in multiple plant species.

Structure of benzothiadiazine at zwitterionic phospholipid cell membranes

This study investigates benzothiadiazine interactions with zwitterionic phospholipid membranes using molecular dynamics simulations to understand its behavior and binding mechanisms.

Morphogenesis and cell ordering in confined bacterial biofilms

This study investigates how confined environments influence biofilm morphology and cell ordering in Vibrio cholerae using single-cell imaging and biomechanical analysis.

Predicting the Conformational Variability of Oncogenic GTP-bound G12D Mutated KRas-4B Proteins at Cell Membranes

The paper develops a computational framework using Molecular Dynamics and Metadynamics to predict conformational variability of G12D mutated KRas-4B proteins at cell membranes, identifying druggable pockets for inhibitor design.

Lentiviral vector optimization enhances the expression and cytotoxicity of chimeric antigen receptors

This study compares single-promoter and dual-promoter lentiviral vectors for CAR expression and cytotoxicity in engineered NK cells, finding that the single-promoter pCDHsp enhances expression and cytotoxicity.

Re-convolving the compositional landscape of primary and recurrent glioblastoma reveals prognostic andtargetable tissue states

The paper identifies three tissue states in glioblastoma microenvironments using snRNAseq and spatial transcriptomics, linking them to metabolic pathways and clinical outcomes.

Hexapeptide induces M2 macrophage polarization via the JAK1/STAT6 pathway to promote angiogenesis in bone repair

This study shows that the hexapeptide WKYMVm promotes M2 macrophage polarization via the JAK1/STAT6 pathway, enhancing angiogenesis in bone repair.

Accurate Virus Identification with Interpretable Raman Signatures by Machine Learning

This paper develops a machine learning model using Raman spectroscopy to accurately identify viruses, achieving high accuracy in classifying virus types and subtypes.

Differential regulation of alternative promoters emerges from unified kinetics of enhancer-promoter interaction

The paper quantifies how two alternative promoters of the Bicoid target gene hunchback are differentially regulated by Bcd through enhancer-promoter interactions in Drosophila embryos.

Biofilm self-patterning: mechanical forces drive a reorientation cascade

This study shows that mechanical forces in Vibrio cholerae biofilms drive a reorientation cascade, creating a core-rim structure through differential growth and compressive stresses.

New metabolic alterations and predictive marker pipecolic acid in sera for esophageal squamous cell carcinoma

This study identifies 12 serum metabolites associated with esophageal squamous cell carcinoma and highlights pipecolic acid as a predictive biomarker for tumorigenesis.

Conformational changes in twitchin kinase in vivo revealed by FRET imaging of freely moving C. elegans

This study uses FRET imaging in C. elegans to show stretch-induced conformational changes in twitchin kinase during muscle activity.

Deep learning for robust and flexible tracking in behavioral studies for C. elegans

This paper applies Faster R-CNN to track C. elegans behavior across different life stages and conditions, demonstrating its flexibility and scalability for large-scale studies.

The Flowering Time Regulator FLK Controls Pathogen Defense in Arabidopsis thaliana

This study identifies FLK as a regulator of pathogen defense in Arabidopsis, showing it affects resistance to bacterial and fungal pathogens through modulation of defense signaling and ROS scavenging.

Precision-targeted metabolomics method characterizes differential metabolomes in multiple-biological matrixes and cell-mitochondria

This paper introduces a precision-targeted metabolomics method capable of analyzing diverse biological matrices and identifies differential metabolomes in rats with CCl4-induced hepatitis.