Author

Y. Toyama

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6 Biophysics· 2 Plant Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 6 Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Research Focus:development & morphogenesis· 3 Assay:imaging· 2 Approach:microscopy & imaging analysis· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

B. Ladoux· 5 shared R.-M. Mege· 3 shared A. P. Le· 2 shared I. Yow· 2 shared J. Prost· 2 shared J.-F. Rupprecht· 2 shared L. Balasubramaniam· 2 shared M. Thomas· 2 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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5 shared papersCell Biology

B. Ladoux

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Golgi-dependent Reactivation and Regeneration of Quiescent Neural Stem Cells

M. R. Gujar, Y. Gao, X. Teng, Q. Deng, Y. S. Tan, Y. Toyama, H. Wang

This study identifies a Golgi-dependent pathway involving Arf1 and Sec71 that regulates microtubule growth and reactivates quiescent neural stem cells in Drosophila.

bioRxiv · Aug 22, 2022 · PreprintCell Biology

Mechanical stress driven by rigidity sensing governs epithelial stability

S. Sonam, L. Balasubramaniam, S.-Z. Lin, I. Yow, I. P. Jauma, C. Jebane, M. Karnat, Y. Toyama, P. Marcq, J. Prost, R.-M. Mege, J.-F. Rupprecht, B. Ladoux

The paper shows that substrate stiffness drives mechanical switches in epithelial monolayers, leading to stochastic failure through topological defects.

bioRxiv · Mar 10, 2022Biophysics

Mechanics defines the spatial pattern of compensatory proliferation

T. Kawaue, I. Yow, A. P. Le, Y. Lou, M. Loberas, M. Shagirov, J. Prost, T. Hiraiwa, B. Ladoux, Y. Toyama

The paper identifies that spatial inhomogeneity in mechanotransduction via YAP drives compensatory proliferation in response to apoptosis.

bioRxiv · Jul 4, 2021 · PreprintCell Biology

Gene expression shapes the patterns of parallel evolution of herbicide resistance in the agricultural weed Monochoria vaginalis

S. Tanigaki, A. Uchino, S. Okawa, C. Miura, K. Hamamura, M. Matsuo, N. Yoshino, N. Ueno, Y. Toyama, N. Fukumi, E. Kijima, T. Masuda, Y. Shimono, T. Tominaga, S. Iwakami

The paper identifies gene expression as a key factor driving parallel evolution of herbicide resistance in Monochoria vaginalis by showing higher expression of specific ALS gene copies.

bioRxiv · Mar 10, 2021Plant Biology

Nature of active forces in tissues: how contractile cells can form extensile monolayers

L. Balasubramaniam, A. Doostmohammadi, T. B. Saw, G. Sankara, R. Mueller, T. Dang, M. Thomas, S. Gupta, S. Sonam, A. S. Yap, Y. Toyama, R.-M. Mege, J. Yeomans, B. Ladoux

The paper investigates how epithelial cell monolayers switch from extensile to contractile behavior as intercellular contacts weaken, revealing mechanotransductive responses and implications for cell sorting and tissue dynamics.

bioRxiv · Oct 28, 2020Biophysics

Adhesion-mediated heterogeneous actin organization governs apoptotic cell extrusion

A. P. Le, J.-F. Rupprecht, R.-M. Mege, Y. Toyama, C. T. Lim, B. Ladoux

This study identifies a dual-mode actin mechanism involving lamellipodia protrusions and purse-string contractility that drives apoptotic cell extrusion in epithelia.

bioRxiv · Aug 26, 2020Cell Biology

Desmosomal coupling in apoptotic cell extrusion

M. Thomas, B. Ladoux, Y. Toyama

This study shows that desmosomal junctions remain intact during apoptotic cell extrusion and are crucial for the process, with actomyosin cables interacting mechanically with desmosomes.

Current Biology · Feb 1, 2020Peer-reviewedCell Biology

Enhancement of endothelialization by topographical features is mediated by PTP1B-dependent endothelial adherens junctions remodeling

A. Gorji, P. J. Y. Toh, Y.-C. Toh, Y. Toyama, P. Kanchanawong

This study shows that PTP1B inhibition combined with grating topography enhances endothelialization by remodeling endothelial adherens junctions and improving cell migration and proliferation.

bioRxiv · Sep 16, 2019Cell Biology

Mechanical Roles of Vinculin/β-catenin interaction in Adherens Junction

C. BERTOCCHI, A. Ravasio, H. T. Ong, Y. Toyama, P. Kanchanawong

The paper investigates the mechanical role of vinculin/β-catenin interaction in adherens junctions, showing that vinculin forms a direct structural connection with β-catenin to support mechanical tension and stabilize complexes.

bioRxiv · Sep 16, 2019Cell Biology