Author

T. Uchihashi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 3 Biophysics· 2 Cancer Biology· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 8 Research Focus:cell signaling & trafficking· 4 Research Focus:cell type annotation· 3 Assay:electronic health records· 2 Approach:microscopy & imaging analysis· 2 Organism:non-human primate· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

S. Tanaka· 2 shared T. Ando· 2 shared A. Sugauchi· 1 shared C. Ganser· 1 shared C. Song· 1 shared D. Ishikuro· 1 shared E. W. Goh· 1 shared H. Fukuzawa· 1 shared

Activity by Year

2017-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

S. Tanaka

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

FliH and FliI help FlhA bring strict order to flagellar protein export in Salmonella

M. Kinoshita, T. Minamino, T. Uchihashi, K. Namba

This study identifies the role of FlhA's GYXLI motif and the flagellar ATPase complex in regulating substrate specificity switching of the fT3SS during flagellar assembly in Salmonella.

bioRxiv · Nov 25, 2023Microbiology

Intratumoral administration of recombinant murine interleukin-12 prevents tumor progression and bone invasion

T. Uchihashi, S. Kasahara, T. Inubushi, K. Kurioka, A. Sugauchi, K. Miyagawa, M. Kogo, S. Tanaka

This study shows that intratumoral IL-12 injection reduces tumor growth and bone resorption in a mouse model of oral squamous cell carcinoma through a T cell-dependent mechanism.

bioRxiv · May 26, 2023Cancer Biology

Ring formation by Vibrio fusion protein composed of FliF and FliG, MS-ring and C-ring component of bacterial flagellar motor in membrane

M. Homma, K. Takahashi, T. Nishikino, H. Kajino, S. Kojima, T. Uchihashi

This study constructs a FliF-FliG fusion protein that enables MS-ring formation in E. coli, revealing its role in flagellar motor assembly and force generation.

bioRxiv · Feb 6, 2023 · PreprintBiochemistry

Decoding of the ubiquitin code for clearance of colliding ribosomes by the RQT complex

Y. Matsuo, T. Inada, T. Uchihashi

The paper investigates how the RQT complex decodes ubiquitin signals to clear colliding ribosomes, showing that Cue3 and Rqt4 interact with K63-linked ubiquitin chains.

Nature Communications · Jan 10, 2023Peer-reviewedBiochemistry

Desiccation-induced fibrous condensation of CAHS protein from an anhydrobiotic tardigrade

M. Yagi-Utsumi, K. Aoki, H. Watanabe, C. Song, S. Nishimura, T. Satoh, S. Yanaka, C. Ganser, S. Tanaka, V. Schnapka, E. W. Goh, Y. Furutani, K. Murata, T. Uchihashi, K. Arakawa, K. Kato

This study investigates the self-assembling properties of CAHS1 protein from tardigrades under desiccation conditions, showing it forms hydrogels and condensates that may contribute to desiccation tolerance.

bioRxiv · Jun 22, 2021Biochemistry

Structural insights into the mechanism of rhodopsin phosphodiesterase

T. Ikuta, W. Shihoya, M. Sugiura, K. Yoshida, M. Watari, T. Tokano, K. Yamashita, K. Katayama, S. P. Tsunoda, T. Uchihashi, H. Kandori, O. Nureki

This study presents the structural and functional analysis of Rh-PDE from Salpingoeca rosetta, revealing its photoactivation mechanism and expanding the definition of rhodopsins.

bioRxiv · Apr 14, 2020 · PreprintBiophysics

Inner lumen proteins stabilize doublet microtubules in cilia/flagella

M. Owa, T. Uchihashi, H. Yanagisawa, T. Yamano, H. Iguchi, H. Fukuzawa, K.-i. Wakabayashi, T. Ando, M. Kikkawa

The paper identifies FAP45 and FAP52 as proteins that stabilize microtubules in cilia by binding to their inner structure and preventing detachment.

bioRxiv · Aug 2, 2018Cell Biology

Dynamic clustering of dynamin-amphiphysin rings regulates membrane constriction and fission coupled with GTP hydrolysis

T. Takeda, T. Kozai, H. Yang, D. Ishikuro, K. Seyama, Y. Kumagai, T. Abe, H. Yamada, T. Uchihashi, T. Ando, K. Takei

This study uses EM and HS-AFM to show dynamin-amphiphysin rings cluster during GTP hydrolysis, driving membrane constriction and fission through a novel clusterase mechanism.

bioRxiv · Aug 20, 2017Biophysics