H. Zhang

The paper analyzes viral genomes from four strains of Rhizoctonia cerealis, identifying 131 novel or unclassified mycoviruses and proposing new taxonomic classifications.

This study identifies let-767 as a gene critical for lipid and ER protein homeostasis, showing that lipid metabolism influences the ER stress response.

This study identifies and characterizes circRNAs in moso bamboo, their biogenesis, function, and response to gibberellins and auxins.

This study identifies genomic signatures of convergent adaptation to high altitudes in alpine plants by analyzing reference genomes and gene expression profiles.

This study shows that eliminating GCN5 in skeletal muscle does not improve mitochondrial content or metabolic markers under high-fat diet conditions, but may influence Pdk4 expression and fat metabolism.

The paper describes a new birch species, Betula mcallisterii, identified through morphology, DNA sequencing, and flow cytometry, with minimal hybridization with its close relative.

The paper presents a high-quality chromosome-scale genome assembly of faba bean and uses it to develop a genotyping assay and dissect hilum color genetics, providing a genomics-based breeding platform for sustainable protein production.

This study shows that reduced GAS6 in synovial macrophages due to M1 polarization impairs efferocytosis, leading to inflammation and cartilage damage in obesity-associated osteoarthritis.

This paper develops a droplet-based method for single-cell transcriptome profiling of TCR-T cells, improving recovery and reducing contamination.

This study identifies a novel monoclonal PD-L1 antibody H1A that enhances T-cell mediated tumor killing in renal cell carcinoma compared to existing PD-1/PD-L1 inhibitors.

The study identifies CsFLC1 in tea plants, showing it influences flowering and bud dormancy, and demonstrates its function in Arabidopsis by promoting early flowering and affecting gene expression related to flowering and hormone pathways.

This study shows that the nonpathogenic bacterium Myxococcus xanthus eliminates the fungal pathogen Cryptococcus neoformans without requiring cell-cell contact, by increasing fungal cell permeability.

The paper identifies HLY72, a small-molecule derivative of lycorine, as an anti-obesity agent that targets Na+/K+-ATPase α3 in the brain, promoting lipolysis and thermogenesis without affecting food intake.

This study uses high-speed AFM to show cohesin-NIPBL captures DNA through arm extension and initiates loop extrusion without ATP hydrolysis, revealing mechanisms of DNA binding and loop formation.

This study identifies ZmGL8 as a key gene regulating the balance between cuticular wax production and jasmonic acid-mediated defenses in maize, showing its role in modulating plant defense responses.

The paper establishes a single-cell atlas of human tooth development and uses it to guide the in vitro differentiation of ameloblasts from iPSCs, developing a mineralizing enamel organoid system.

This study evaluates neutralization of Omicron sub-lineages by booster vaccination or BA.2 breakthrough infection sera using a pseudovirus panel.

This study develops an Omicron-specific mRNA vaccine that shows superior neutralizing antibody responses in mice, hamsters, and macaques compared to existing vaccines.

The paper reports cryo-EM structures of FSHR in inactive and active states, revealing a conserved activation mechanism and the role of H6157.42 in agonist selectivity.

The paper shows that beta 1 adrenergic receptor-generated cAMP pools at distinct membrane locations regulate cardiac contraction and relaxation through different PKA targets.

This study identifies TUT1-regulated alternative splicing of NCOR2 producing NCOR2-013 as a mechanism by which Talaromyces marneffei suppresses macrophage inflammation.

REST is a deep learning method that restores cryo-ET density maps by denoising and compensating for missing wedge effects, enabling visualization of individual macromolecules.

The paper presents a near-atomic structure of the NuA4 complex and shows it has auto-inhibited conformation that becomes active upon substrate and co-factor binding.

The paper integrates single-nucleus and spatial transcriptomics to map transitional states in soybean nodule symbiosis, identifying functionally distinct cell subgroups and a transitional infected cell subtype.

This study computes binding free energies of Yoda1 and its analogs at Piezo1 channels using molecular dynamics to predict agonist/inhibitor effects and guide drug design.

The paper creates a database of intron splicing efficiency across multiple plant species using public RNA-seq data to explore how splicing varies with treatments and genetic mutants.

This study shows ethylene improves root hypoxia tolerance by reducing reactive oxygen species and inducing growth cessation in Arabidopsis thaliana.

This study identifies myostatin upregulation in paravertebral muscle cells as a driver of oxidative stress and apoptosis, contributing to idiopathic scoliosis development.

The paper develops a computational model to study the mechanisms of treatment-free remission in CML patients, revealing the role of the neoplastic microenvironment and leukemia stem cell dynamics.

This study shows that pathogens like Brucella and coronavirus MHV exploit the RIDD pathway to degrade BLOS1, impairing lysosomal trafficking and enhancing their intracellular survival.