H. Zhang

This study shows that in C. elegans, D-2HG is produced via the propionate shunt and that loss of dhgd-1 causes embryonic lethality by disrupting ketone body metabolism, which can be rescued by vitamin B12 or 3-hydroxybutyrate.

This study develops a regenerative immunotherapy using helminth-derived soluble egg antigen to promote tissue repair in multiple injury models.

This paper shows that teicoplanin inhibits SARS-CoV-2 cell entry by blocking cathepsin L proteolytic activity, effective against multiple variants with IC50 values of 2.038 M and 2.116 M.

This paper identifies a potent antibody cocktail that synergistically neutralizes SARS-CoV-2 and its variants, including Omicron BA.1 and BA.2.

This study shows that HCMV inactivates AKT to promote FOXO3a nuclear localization, which is required for efficient viral replication.

The paper presents a single-cell transcriptomic atlas of Macaca fascicularis, identifying cell interactions and disease associations.

The paper shows that waterbird community composition strongly predicts HPAI H5 occurrence in wild birds across different epidemics, with similar patterns observed for H5N8 and H5N1.

The paper introduces the Swarm, a high-throughput optogenetic platform for screening ion channel modulators in excitable cells, demonstrating its utility in drug discovery for nervous system disorders and cardiac toxicity.

The study shows that soil intake in mice increases gut microbial diversity and reduces serum IgE levels, suggesting potential prebiotic effects.

This study identifies climate-associated genetic variants in Populus koreana and predicts its future climate change vulnerability using genomic and environmental data.

This study identifies GlnZ, a 3' UTR-derived sRNA in E. coli that regulates carbon and nitrogen metabolism by repressing glnP and sucA, enhancing survival under nitrogen limitation.

The paper identifies a C-terminal glutamine recognition mechanism by TRIM7 that targets viral proteins, revealing its role in antiviral defense against norovirus and SARS-CoV-2.

The paper uses single-cell RNA sequencing to identify novel cell subsets in subchondral bone of OA patients and elucidates their roles in disease progression.

The paper shows that moenomycin inhibits PBP1a2, leading to pole degradation by DacB in Myxococcus xanthus, revealing coordination between PG synthases and hydrolases is critical for cell integrity.

This study uses [18F]-PARPZ PET imaging to assess alpha particle radiotherapy response in prostate cancer xenografts by tracking PARP-1 expression changes.

The paper uses a process-based model to identify contrasting trait networks in maize that enhance growth and water use in different environments.

This study identifies HERV activation in BA livers and shows it re-educates macrophages, impairing neutrophil recruitment and causing liver damage, suggesting therapeutic targets.

This study links TOP1MT deficiency and the P193L variant to mtDNA release and cGAS-STING activation, contributing to autoimmune disease susceptibility.

This paper develops hetero-bivalent nanobodies that neutralize multiple SARS-CoV-2 variants, including Omicron, and show protective effects in vivo.

This study develops a scalable workflow for targeted single-nucleus DNA sequencing in pancreatic cancer, enabling high-resolution genomic analysis of tumor subclones and normal cells.

PPRD integrates and curates ~45,000 plant RNA-seq libraries into a searchable database to facilitate expression analysis.

This study shows how natural selection rapidly reshapes developmental gene regulatory networks in sea urchins with divergent life histories, revealing evolutionary changes in gene regulation and chromatin status.

This study investigates enrofloxacin's ability to cross the blood-brain barrier in crucian carp and its impact on brain injury markers.

This study develops a chitosan-L-arginine complex for gene delivery, showing high encapsulation efficiency and enhanced cellular uptake of siRNA in cancer cells.

This study shows that combining fecal microbiota transplantation with anti-PD-1 therapy improves survival and tumor control in mice, with specific gut bacteria and metabolites contributing to the enhanced efficacy.

This paper develops lyophilized mRNA-lipid nanoparticle vaccines that maintain stability at room temperature and show high antigenicity against SARS-CoV-2 variants in preclinical and human trials.

The paper shows that actin dynamics determine apical membrane domain positioning in C. elegans intestine, independent of PAR proteins, by directing vesicle trajectories toward the future apical domain.

LIFE-Seq is a method for analyzing transgene integration in GMOs using DNA probes and PacBio sequencing, offering improved accuracy and cost-effectiveness compared to whole-genome sequencing.