Author

Hong Gu

Allen Institute for Brain SciencePrimary ORCID profile (0000-0001-6496-0383 · 5 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Hong GuiD5 papers · National Institutes of Health

Biology Disciplines

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Neuroscience· 6

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Research Focus:cell type annotation· 6 Organism:mouse· 6 Approach:experimental assay· 4 Approach:statistical model· 4 Assay:scRNA-seq· 3 Research Focus:clustering· 2 Research Focus:differential expression· 2 Assay:electronic health records· 2

Frequent Co-Authors

Medea McGrawiD· 6 shared Amanda GaryiD· 5 shared Jonathan T. TingiD· 5 shared Krissy BrouneriD· 5 shared Lydia PotekhinaiD· 5 shared Philip R. NicovichiD· 5 shared Tanya L. DaigleiD· 5 shared Tom EgdorfiD· 5 shared

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2018-2026 · peak 2/yr

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10 top collaborators · 45 mutual co-author links

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6 shared papersNeuroscience

Medea McGrawORCID

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6 papers

Recent·Most cited

Connecting single neuron transcriptomes to the projectome in mouse visual cortex

Staci A. Sorensen, Nathan W. Gouwens, Yun Wang, Matthew Mallory, Agata Budzillo, Rachel A. Dalley, Brian Lee, Olga Gliko, Hsien-Chi Kuo, Xiuli Kuang, Rusty Mann, Leila Ahmadinia, Lauren Alfiler, Fahimeh Baftizadeh, Katherine S. Baker, , Adrian Andreas Wanner

The paper integrates transcriptomic, morphological, and electrophysiological data to define neuron types in mouse visual cortex and predict their projection targets.

Nature · Jul 1, 2026Peer-reviewedNeuroscience

A whole-brain monosynaptic input connectome to neuron classes in mouse visual cortex

Shenqin Yao, Quanxin Wang, Karla E. Hirokawa, Benjamin Ouellette, Ruweida Ahmed, Jasmine Bomben, Krissy Brouner, Linzy Casal, Shiella Caldejon, Andy Cho, Nadezhda I. Dotson, Tanya L. Daigle, Tom Egdorf, Rachel Enstrom, Amanda Gary, , Hongkui Zeng

The paper maps brain-wide monosynaptic inputs to specific neuron classes in mouse visual cortex using an improved rabies virus tracing strategy and identifies connectivity patterns within and between visual areas.

Nature Neuroscience · Dec 22, 2022Peer-reviewedNeuroscience

Toward an integrated classification of neuronal cell types: morphoelectric and transcriptomic characterization of individual GABAergic cortical neurons

Nathan W. Gouwens, Staci A. Sorensen, Fahimeh Baftizadeh, Agata Budzillo, Brian Lee, Tim Jarsky, Lauren Alfiler, Katherine S. Baker, Eliza R. Barkan, Kyla Berry, Darren Bertagnolli, Kris Bickley, Jasmine Bomben, Thomas Braun, Krissy Brouner, , Hongkui Zeng

The paper characterizes transcriptomic and physiological properties of GABAergic cortical neurons in mice, identifying 20 interneuron met-types with consistent features across modalities.

Cell · Nov 1, 2020Peer-reviewedNeuroscience

Human cortical expansion involves diversification and specialization of supragranular intratelencephalic-projecting neurons

Jim Berg, Staci A. Sorensen, Jonathan T. Ting, Jeremy A. Miller, Thomas Chartrand, Anatoly Buchin, Trygve E. Bakken, Agata Budzillo, Nick Dee, Song‐Lin Ding, Nathan W. Gouwens, Rebecca D. Hodge, Brian E. Kalmbach, Changkyu Lee, Brian Lee, , Josef Šulc

The paper identifies transcriptomic diversity in human supragranular neurons and links it to functional specialization and disease vulnerability.

bioRxiv · Mar 31, 2020 · PreprintNeuroscience

Classification of electrophysiological and morphological types in mouse visual cortex

Nathan W. Gouwens, Staci A. Sorensen, Jim Berg, Changkyu Lee, Tim Jarsky, Jonathan T. Ting, Susan M. Sunkin, David H. Feng, Costas A. Anastassiou, Eliza R. Barkan, Kris Bickley, Nicole Blesie, Thomas Braun, Krissy Brouner, Agata Budzillo, , Christof Koch A

The paper classifies neurons in mouse visual cortex into 17 electrophysiological and 35 morphological types using unsupervised methods and links them to transcriptomic types.

Nature Neuroscience · Jun 17, 2019Peer-reviewedNeuroscience

A suite of transgenic driver and reporter mouse lines with enhanced brain cell type targeting and functionality

Tanya L. Daigle, Linda Madisen, Travis A Hage, Matthew T. Valley, Ulf Knoblich, Rylan S. Larsen, Marc M. Takeno, Lawrence Huang, Hong Gu, Rachael Larsen, Maya Mills, Alice Bosma-Moody, La’Akea Siverts, Miranda Walker, Lucas T. Graybuck, , Hongkui Zeng

The paper introduces a new set of transgenic mouse lines for precise targeting and manipulation of brain cell types, enhancing genetic tools for neuroscience research.

Cell · Jan 1, 2018Peer-reviewedNeuroscience