Author

E. C. Gale

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:drug response / drug discovery· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell-cell communication· 1 Assay:proteomics· 1

Frequent Co-Authors

E. Appel· 4 shared A. E. Powell· 3 shared A. K. Grosskopf· 3 shared B. S. Ou· 3 shared C. L. Maikawa· 3 shared J. Yan· 3 shared B. Pulendran· 2 shared E. A. Appel· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersBioengineering

E. Appel

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Nanoparticle-Conjugated TLR9 Agonists Improve the Potency, Durability, and Breadth of COVID-19 Vaccines

B. S. Ou, J. Baillet, V. C. T. M. Picece, E. C. Gale, A. E. Powell, O. M. Saouaf, J. Yan, A. Nejatfard, H. Lopez Hernandez, E. Appel

This paper develops CpG nanoparticle adjuvants that enhance the potency, durability, and breadth of COVID-19 vaccines by improving antigen delivery and immune response.

bioRxiv · Jan 2, 2023 · PreprintBioengineering

A cGAMP-containing hydrogel for prolonged SARS-CoV-2 RBD subunit vaccine exposure induces a broad and potent humoral response

V. Böhnert, E. C. Gale, L. J. Lahey, J. Yan, A. E. Powell, B. S. Ou, J. A. Carozza, L. Li, E. Appel

A cGAMP-containing hydrogel vaccine enhances RBD subunit vaccine efficacy by enabling sustained antigen and adjuvant delivery, resulting in broader and more potent antibody responses.

bioRxiv · Jul 3, 2021 · PreprintBioengineering

Injectable Nanoparticle-Based Hydrogels Enable the Safe and Effective Deployment of Immunostimulatory CD40 Agonist Antibodies

S. Correa, E. C. Gale, A. T. Mayer, Z. Xiao, C. Liong, J. H. Klich, R. A. Brown, E. L. Meany, O. M. Saouaf, C. L. Maikawa, A. K. Grosskopf, J. L. Mann, J. Idoyaga, E. Appel

This paper develops injectable hydrogels to safely deliver CD40 agonist antibodies, reducing toxicity while maintaining anti-cancer efficacy in a melanoma model.

bioRxiv · Jun 27, 2021Bioengineering

Consistent Tumorigenesis with Self-Assembled Hydrogels Enables High-powered Murine Cancer Studies

A. K. Grosskopf, S. Correa, J. Baillet, C. L. Maikawa, E. C. Gale, R. A. Brown, E. A. Appel

This paper introduces a hydrogel-based tumor inoculation method that reduces variability in murine tumor growth, enabling more efficient and reliable cancer studies.

bioRxiv · Apr 13, 2021Bioengineering

Hydrogel-based slow release of a receptor-binding domain subunit vaccine elicits neutralizing antibody responses against SARS-CoV-2

E. C. Gale, A. E. Powell, G. A. Roth, E. L. Meany, J. Yan, B. S. Ou, A. K. Grosskopf, J. Adamska, V. C. T. M. Picece, A. I. d'Aquino, B. Pulendran, P. S. Kim, E. Appel

This study shows that slow release of an RBD subunit vaccine via hydrogel enhances neutralizing antibody responses against SARS-CoV-2 compared to bolus administration.

bioRxiv · Mar 31, 2021Bioengineering

Injectable hydrogels for sustained co-delivery of subunit vaccines enhance humoral immunity

G. A. Roth, E. C. Gale, M. Alcantara-Hernandez, W. Luo, E. Axpe, R. Verma, Q. Yin, A. C. Yu, H. Lopez Hernandez, C. L. Maikawa, A. A. A. Smith, M. M. Davis, B. Pulendran, J. Idoyaga, E. A. Appel

This paper introduces an injectable hydrogel platform for sustained co-delivery of subunit vaccines, which enhances humoral immunity by improving antigen and adjuvant presentation over time.

bioRxiv · May 26, 2020Bioengineering