J. Li

This paper develops a CRISPR-Cas13b-based tool to specifically demethylate m6A modifications on target mRNAs, enhancing their stability and demonstrating efficient gene regulation with minimal off-target effects.

This study extends the in vivo haploid induction system from diploid maize to hexaploid wheat by knocking out homologous genes, achieving 2%-3% haploid induction with 30%-60% seed setting rate.

This study shows that activating the GPER receptor with G-1 inhibits PDAC growth, reduces c-Myc and PD-L1, and enhances immunotherapy response in mouse models and human tumors.

This study identifies transcriptomic changes in guard cells of M. crystallinum during salt-induced C3 to CAM transition, showing guard cells can undergo this shift.

This study shows that activating Piezo1 channels in cardiac fibroblasts reduces myofibroblast differentiation and increases IL-6 secretion through Ca2+-dependent p38 MAP kinase activation.

This study identifies a non-canonical role for PLK4 in fibroblast cell-type transition and shows its regulation by BRD4 and PDGFR pathways, suggesting PLK4 inhibition as a potential anti-fibrotic intervention.

The paper improves non-viral CRISPR-Cas9 genome editing in immune cells by using truncated Cas9 target sequences and polymer-stabilized nanoparticles, enhancing efficiency and viability.

The paper shows Nilotinib inhibits Hedgehog signaling in medulloblastoma by directly targeting Smoothened, outperforming Vismodegib in cell lines and xenograft models.

This study examines how drought affects the antioxidant system and stomatal aperture in Zanthoxylum bungeanum by analyzing enzyme activities, gene expression, and stomatal changes under drought conditions.

The paper identifies SOX6 as a therapeutic target in Ewing sarcoma by showing its role in elevating ROS levels, making the disease vulnerable to ROS-inducing drugs.

This study investigates the selectivity of 4-aminoquinolines for the alpha2A-adrenoceptor using docking, molecular dynamics, and mutagenesis to identify binding sites and affinity determinants.

This paper develops a portable 2D gas chromatography device with machine learning to diagnose ARDS from breath samples, achieving 87.1% accuracy.

This study identifies subtype-specific prognostic biomarkers in prostate adenocarcinoma, showing that their prognostic value depends on TMPRSS2-ERG fusion status.

This paper shows that papillomavirus can be transmitted through blood and cause infections in animal models, suggesting blood transfusion as a potential route for HPV infection and cancer in humans.

This study examines how antibiotic treatment affects the human gut resistome, showing increased resistance gene diversity and horizontal gene transfer potential.

This study identifies colibactin-645 as a genotoxic metabolite that induces DNA double-strand breaks via a copper-mediated oxidative mechanism, revealing its role in colorectal cancer progression.

The paper detects Leishmania spp. in snakes from Northwest China and identifies three species using phylogenetic analysis.

This study shows chronic stress increases oxytocin levels, which promotes melanoma metastasis via β-arrestin 2-dependent pathways, suggesting OXT as a therapeutic target.

This study identifies TIM-1 and endocytic pathways as key mediators of exosome entry and cargo delivery for IFN-α-induced antiviral activity transfer from macrophages to hepatocytes.

This study identifies CALCB as a direct EWSR1-FLI1 target in Ewing sarcoma and shows that targeting the CALCB/RAMP1-axis inhibits tumor growth.

This study identifies the role of CstIV and CstV in C. coli lipooligosaccharide biosynthesis, showing cstV is involved in sialylation and cstIV in adding a diacetylated nonulosonic acid residue.

This study identifies SMARCB1 loss as critical for RMC survival and shows proteasome inhibition as a potential therapeutic strategy.

This paper identifies Spc105 as a new LaeA interaction partner in Aspergillus flavus, showing its role in development, secondary metabolism, and regulatory interdependence with LaeA.

This study validates eDNA metabarcoding as a reliable method for monitoring fish communities in lakes, showing strong correlation with expected species and ecological community classification.

This study identifies KDM4D as a key regulator of hepatic fibrosis by modulating TLR4 signaling through histone demethylation in HSCs.

This study investigates the biosorption of Pb(II) and Zn(II) by Verticillium insectorum J3, finding that it absorbs Pb(II) preferentially and shows enhanced biosorption at higher concentrations.

The paper identifies an R2R3-MYB activator and an R3-MYB repressor in monkeyflowers that fit Turing's reaction-diffusion model and explain periodic pigment spot formation.

This study shows that exogenous calcium ions increase Saccharomyces cerevisiae cell wall thickness and patulin adsorption by enhancing key enzyme activities.

This study identifies a novel maize gene, glossy6, involved in epicuticular wax trafficking and drought tolerance by analyzing a mutant with reduced wax load and increased water loss.