Author

J. S. Freundlich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:Arabidopsis· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. E. Jerse· 1 shared B. Aldridge· 1 shared B. Kreiswith· 1 shared D. M. Ando· 1 shared D. S. Perlin· 1 shared E. Geisinger· 1 shared E. Hamami· 1 shared E. Singleton· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperMicrobiology

A. E. Jerse

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Author profile →

3 papers

Recent·Most cited

Loss of essential outer membrane functions causes drug hypersensitization in Acinetobacter baumannii overexpressing multidrug efflux pumps

E. Hamami, W. Huo, K. Neal, I. Neisewander, S. Fnu, J. S. Freundlich, E. Geisinger, R. R. Isberg

The paper identifies essential genes in Acinetobacter baumannii that support efflux pump overproducer fitness during ciprofloxacin treatment, revealing roles in outer membrane integrity and pH homeostasis.

bioRxiv · Jan 4, 2024Microbiology

A novel oral GyrB/ParE dual binding inhibitor effective against multidrug resistant Neisseria gonorrhoeae and other high-threat pathogens

S. Park, R. Russo, L. Westfall, R. Shrestha, M. Zimmerman, V. A. Dartois, N. Kurepina, B. Kreiswith, E. Singleton, S.-G. LI, N. Mittal, Y.-M. Ahn, j. Bilotta, K. L. Connolly, A. E. Jerse, , D. S. Perlin

The paper describes a novel oral inhibitor, JSF-2659, effective against multidrug-resistant Neisseria gonorrhoeae and other high-threat pathogens, with low potential for resistance development.

bioRxiv · Mar 23, 2022Microbiology

Morphological profiling of tubercule bacilli identifies drug pathways of action

T. C. Smith, K. M. Pullen, M. C. Olson, M. E. McNellis, I. Richardson, S. Hu, J. Larkins-Ford, X. Wang, J. S. Freundlich, D. M. Ando, B. Aldridge

This paper introduces MorphEUS, a morphological profiling method that classifies drugs based on their effects on Mycobacterium tuberculosis morphology, identifying both primary and off-target pathways of action.

bioRxiv · Mar 11, 2020Microbiology