J. Yuan

This study identifies PCSK9 as a target to enhance CD8+ T cell antitumor activity by modulating LDLR and TCR signaling in the tumor microenvironment.

This paper develops a 3D reconstruction method using ATUM-SEM and deep learning to analyze hepatic organelle interactions and their morphology.

The paper develops a proteomics platform to identify off-target proteins affected by PROTAC and RNAi therapies, using a selected off-target proteome and LC-MS/MS quantification.

This study identifies TFR1, SAHH, and HV307 as potential biomarkers for colorectal cancer screening through proteomics analysis of pre-cancerous to cancerous tissues.

The paper identifies a corneal mitochondrial susceptibility module linked to SARS-CoV-2 infection by analyzing co-expression and interaction networks of ACE2 and related genes.

This study develops CRISPR/Cas12a for genome editing and transcriptional repression in R. capsulatus, achieving high editing and repression efficiencies.

This study identifies Dhx36 as essential for skeletal muscle stem cell regeneration by regulating mRNA translation through binding and unwinding 5' UTR G-quadruplex structures.

This paper develops a deep learning system for gastric cancer detection using histopathological images, achieving high sensitivity and robust performance across different scanners.

This study investigates how mutations in MgrB affect its ability to inhibit PhoQ, revealing key residues and regions critical for its function.

The paper shows that NORTIA accumulation at the filiform apparatus is essential for pollen tube reception in Arabidopsis thaliana.

This study isolates and characterizes 206 RBD-specific monoclonal antibodies from SARS-CoV-2 infected individuals, finding diverse neutralizing activity and species-specific antibody responses.

The paper uses cryo-EM to reveal the post-fusion structure of SARS-CoV-2, showing the S protein in a state with S1 disassociated.

This study identifies splicing-dependent RNA-fusions in neuroblastoma and shows spliceosome inhibition reduces tumor growth.

This study examines gut microbiome differences between lung cancer patients and healthy individuals, finding altered microbial composition but unclear links to cancer development.

The paper identifies a novel Mycobacterium tuberculosis-specific CD4+IFN-γ+ T cell subset with naive-like markers that provides better protection against TB than central or effector memory T cells.

This study identifies NERD1 as a regulator of ovule number and fertility in Arabidopsis using genome-wide association and mutant analysis.

This study uses single-cell RNA-Seq to analyze lineage diversity and microenvironment in high-grade gliomas, finding links between cellular identity, proliferation, and population structure.

This study shows that β-lactam antibiotics increase MRSA pathogenicity by upregulating the tlpps gene cluster via SarA, leading to enhanced inflammation and infection severity.

This study identifies dimer-dependent catalytic activity in RAF family kinases through analysis of oncogenic mutants, revealing differential inhibitor resistance and MEK phosphorylation mechanisms.

This study examines how different stocking densities affect the liver proteome and cecal microbiota of Peking ducks, revealing oxidative stress and inflammation trends in high-density groups.

This study uses single-molecule long-read sequencing to analyze red clover transcriptome, identifying novel splice isoforms, alternative splicing events, and non-coding RNAs.

This study identifies AMPKi as a compound that blocks 14-3-3 binding to CRAF, overcoming RAF inhibitor resistance by preventing paradoxical CRAF activation in cancer cells.

This study investigates how 1,25-dihydroxyvitamin D3 and fluid shear stress together affect osteoblast function, showing their combined impact on nitric oxide release, proliferation, PGE2 release, and differentiation.