Author

Jennifer C. McCreight

23andMe (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 5 Genetic & Genomic Medicine· 3 Genomics· 2

Signature Assays, Organisms & Methods

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Organism:human· 9 Approach:statistical model· 9 Research Focus:GWAS / association mapping· 7 Assay:GWAS summary statistics· 6 Assay:electronic health records· 2 Research Focus:fine-mapping· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Aaron Kleinman· 10 shared Adam AutoniD· 10 shared Janie F. Shelton· 10 shared Joanna L. MountainiD· 10 shared Joyce Y. TungiD· 10 shared Karen E. Huber· 10 shared Katarzyna BryciD· 10 shared Matthew H. McIntyreiD· 10 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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10 shared papersGenetics

Aaron Kleinman

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Author profile →

10 papers

Recent·Most cited

Discovery of genomic loci associated with sleep apnoea risk through multi-trait GWAS analysis with snoring

Adrián I. Campos, Nathan Ingold, Yunru Huang, Brittany L. Mitchell, Pik Fang Kho, Xikun Han, Luis M. García‐Marín, Jue‐Sheng Ong, Michelle Agee, Stella Aslibekyan, Adam Auton, Elizabeth Babalola, Robert K. Bell, Jessica Bielenberg, Katarzyna Bryc, , Miguel E. Rentería

This study identifies 49 genetic loci associated with sleep apnoea risk using multi-trait GWAS, with 29 replicated in a large cohort, and finds genetic correlations with several complex traits.

SLEEP · Dec 16, 2022Peer-reviewedGenetic & Genomic Medicine

Resource Profile and User Guide of the Polygenic Index Repository

Joël Becker, Casper A.P. Burik, Grant Goldman, Nancy Wang, Hariharan Jayashankar, Michael Bennett, Daniel W. Belsky, Richard Karlsson Linnér, Rafael Ahlskog, Aaron Kleinman, David A. Hinds, Michelle Agee, Babak Alipanahi, Adam Auton, Robert K. Bell, , Aysu Okbay

The paper constructs polygenic indexes for 47 phenotypes across 11 datasets and provides a tool to correct errors-in-variables bias when using PGIs as proxies for the additive SNP factor.

Nature Human Behaviour · Jun 17, 2021Peer-reviewedGenomics

Genetic determinants of daytime napping and effects on cardiometabolic health

Hassan S. Dashti, Iyas Daghlas, Jacqueline M. Lane, Yunru Huang, Miriam S. Udler, Heming Wang, Hanna Maria Ollila, Samuel E. Jones, Jaegil Kim, Andrew R. Wood, Michelle Agee, Adam Auton, Robert K. Bell, Katarzyna Bryc, Sarah K. Clark, , Richa Saxena

This study identifies genetic loci associated with daytime napping and finds potential causal links between napping and cardiometabolic traits.

Nature Communications · Feb 10, 2021Peer-reviewedGenetic & Genomic Medicine

Genome-wide study identifies association between HLA-B*55:01 and penicillin allergy

Kristi Krebs, Jonas Bovijn, Neil S. Zheng, Maarja Lepamets, Jenny C. Censin, Tuuli Jürgenson, Dage Särg, Erik Abner, Triin Laisk, Yang Luo, Line Skotte, Frank Geller, Bjarke Feenstra, Wei Wang, Adam Auton, , João Fadista

The paper identifies HLA-B*55:01 as a genetic risk factor for penicillin allergy through genome-wide analysis of electronic health records and imputed HLA data.

The American Journal of Human Genetics · Sep 3, 2020Peer-reviewedGenetics

Genome-wide association and multi-omic analyses reveal new mechanisms for Heart Failure

Marios Arvanitis, Emmanouil Tampakakis, Yanxiao Zhang, Wei Wang, Adam Auton, Michelle Agee, Stella W. Aslibekyan, Robert K. Bell, Katarzyna Bryc, Sarah Clark, Sarah L. Elson, Kipper Fletez‐Brant, Pierre Fontanillas, Nicholas A. Furlotte, Pooja Gandhi, , Alexis J. Battle

This study identifies one known and two novel genetic variants associated with heart failure through GWAS and multi-omic analyses, revealing potential causal mechanisms and shared heritability with musculoskeletal traits.

Nature Communications · Feb 28, 2020Peer-reviewedGenetic & Genomic Medicine

Characterization of prevalence and health consequences of uniparental disomy in four million individuals from the general population

Priyanka Nakka, Samuel Pattillo Smith, Anne O’Donnell‐Luria, Kimberly F. McManus, Michelle Agee, Adam Auton, Robert K. Bell, Katarzyna Bryc, Sarah L. Elson, Pierre Fontanillas, Nicholas A. Furlotte, Barry Hicks, David A. Hinds, Ethan M. Jewett, Yunxuan Jiang, , J. Fah Sathirapongsasuti

The paper characterizes the prevalence and health consequences of uniparental disomy in four million individuals, identifying 675 cases and linking UPD of chromosome 22 to autism.

The American Journal of Human Genetics · Oct 10, 2019Peer-reviewedGenomics

A genome-wide association study identifies that the GDF5 and COL27A1 genes are associated with knee pain in UK Biobank (N = 171, 516)

Weihua Meng, Mark J. Adams, Colin N. A. Palmer, Michelle Agee, Babak Alipanahi, Robert K. Bell, Katarzyna Bryc, Sarah L. Elson, Pierre Fontanillas, Nicholas A. Furlotte, Barry Hicks, David A. Hinds, Karen E. Huber, Ethan M. Jewett, Yunxuan Jiang, , Blair Hamilton Smith

This study identifies two genetic loci, GDF5 and COL27A1, associated with knee pain through a genome-wide association analysis in the UK Biobank and replication in other cohorts.

Communications Biology · Aug 28, 2019Peer-reviewedGenetics

Genome-wide association studies of impulsive personality traits (BIS-11 and UPPSP) and drug experimentation in up to 22,861 adult research participants

Sandra Sanchez‐Roige, Pierre Fontanillas, Sarah L. Elson, Michelle Agee, Babak Alipanahi, Adam Auton, Robert K. Bell, Katarzyna Bryc, Nicholas A. Furlotte, David A. Hinds, Karen E. Huber, Aaron Kleinman, Nadia K. Litterman, Jennifer C. McCreight, Matthew H. McIntyre, , Abraham A. Palmer

This study conducts GWAS on impulsive personality traits and drug experimentation in 22,861 adults, identifying genetic associations and correlations with psychiatric disorders.

Journal of Neuroscience · Feb 4, 2019Peer-reviewedGenetics

Common variant burden contributes significantly to the familial aggregation of migraine in 1,589 families

Padhraig Gormley, Mitja Kurki, Marjo Eveliina Hiekkala, Kumar Veerapen, Paavo Häppölä, Adele A. Mitchell, Dennis Lal, Priit Palta, Ida L. Surakka, Mari Anneli Kaunisto, Eija Hämäläinen, Salli Vepsäläinen, Hannele Havanka, Hanna Harno, Matti Ilmavirta, , George McMahon

This study shows common genetic variants significantly contribute to migraine family clustering, with higher burden in familial cases compared to population-based cases.

Neuron · May 1, 2018Peer-reviewedGenetics

Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways

David M. Howard, Mark J. Adams, Masoud Shirali, Toni‐Kim Clarke, Riccardo Emilio Marioni, Gail Davies, Jonathan R. I. Coleman, Clara Alloza, Xueyi Shen, Miruna C. Barbu, Eleanor M. Wigmore, Jude Gibson, Michelle Agee, Babak Alipanahi, Adam Auton, , Andrew Mark McIntosh

This study conducts a GWAS on depression phenotypes in UK Biobank, identifying genetic variants enriched in excitatory synaptic pathways.

Nature Communications · Apr 11, 2018Peer-reviewedGenetics