K. Hu

This paper defines the reprogramome as the full set of genes reprogrammed to pluripotency and quantifies reprogramming using a mathematical model, revealing key pathways involved in fibroblast reprogramming to PSCs.

This study identifies TgDCX, a Toxoplasma protein that binds and modifies tubulin polymers, enabling curved structures critical for parasite invasion.

The paper assesses the frequency of deleterious mutations in 21 hereditary breast and ovarian cancer genes among 882 high-risk Chinese individuals, finding 19.5% carried such mutations, with higher rates in those with both breast and ovarian cancer histories.

This study evaluates the methodological quality of animal studies using the SYRCLEs risk of bias tool, finding significant differences between Chinese and English studies.

This study identifies TgCentrin2's role in Toxoplasma gondii by showing its necessity for invasion and replication through functional characterization.

The paper screens monoclonal antibodies for cross-reactivity in non-human primates and develops immunophenotyping panels for CyTOF.

This paper reports the crystal structure of T. gondii AKMT, revealing a unique dimerization interface and distinct structural features that define a new subclass of KMTs.

This study identifies PafE as an ATP-independent proteasome activator in M. tuberculosis, revealing its mechanism of substrate capture and gate activation through structural and functional analyses.

This study investigates the role of the apical polar ring in Toxoplasma gondii by analyzing KinesinA and APR1, showing its structural importance for microtubule organization and parasite function.