G. K. Fragiadakis

Integrated longitudinal multi-omics study identifies immune programs associated with COVID-19 severity and mortality in 1152 hospitalized participants

This study identifies immune programs linked to COVID-19 severity and mortality through longitudinal multi-omics analysis of 1,152 hospitalized patients.

Deciphering Cell-types and Gene Signatures Associated with Disease Activity in Rheumatoid Arthritis using Single Cell RNA-sequencing

This study uses single-cell RNA sequencing of PBMCs from RA patients and controls to identify disease-associated cell subsets and gene signatures linked to RA disease activity.

Commensal myeloid crosstalk in neonatal skin regulates cutaneous type 17 inflammation

This study shows that commensal microbes in neonatal skin promote immune homeostasis by regulating monocyte accumulation and IL-17A production by T cells.

Cyclone: an accessible pipeline to analyze, evaluate and optimize multiparametric cytometry data

Cyclone is a pipeline for analyzing, evaluating, and optimizing multiparametric cytometry data, demonstrating effectiveness across multiple cytometry technologies and biological contexts.

Single-cell and spatial multi-omics highlight effects of anti-integrin therapy across cellular compartments in ulcerative colitis

This study uses single-cell and spatial multi-omics to show VDZ affects mononuclear phagocyte subsets and highlights gene expression patterns in UC.

Homeostatic cytokines reciprocally modulate the emergence of prenatal effector PLZF+CD4+ T cells in humans

This study identifies how IL-7 drives the expansion and effector function of prenatal PLZF+ CD4+ T cells in humans, influencing their tissue distribution and differentiation.

Gut Microbiota-Targeted Diets Modulate Human Immune Status

This study examines how plant-based fiber and fermented food diets affect the gut microbiome and immune system in healthy adults over 17 weeks.

A Pan-Cancer Census of Dominant Tumor Immune Archetypes

The paper identifies dominant immune system archetypes across 364 tumors from 12 cancer types using flow cytometry and transcriptomic data, linking them to tumor biology classifications.

Longitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19

The paper examines IFN-I autoantibodies in critical COVID-19 patients through longitudinal single-cell analysis, revealing suppressed ISG-I responses in myeloid cells.

Global Absence and Targeting of Protective Immune States in Severe COVID-19.

The paper identifies that severe COVID-19 patients lack ISG-expressing cells and have antibodies that block their production, contrasting with mild cases.

Long-term dietary intervention reveals resilience of the gut microbiota despite changes in diet and weight

This study tracks gut microbiota changes over 12 months in response to low-carbohydrate or low-fat diets, finding initial shifts followed by resilience to long-term perturbation.

Cell type-specific monoclonal antibody cross-reactivity screening in non-human primates and development of comparative immunophenotyping panels for CyTOF

The paper screens monoclonal antibodies for cross-reactivity in non-human primates and develops immunophenotyping panels for CyTOF.

A comprehensive atlas of immunological differences between humans, mice and non-human primates

The paper compares immunological differences between humans, mice, and non-human primates using CyTOF mass cytometry, identifying species-specific immune responses and correlations with viral serostatus.

Variation of immune cell responses in humans reveals sex-specific coordinated signaling across cell types

The paper profiles immune cell responses in humans to identify sex-specific signaling patterns and provides reference ranges for immune markers.

Links between environment, diet, and the hunter-gatherer microbiome

The paper examines the microbiome of Hadza hunter-gatherers, finding seasonal changes and unique bacterial families compared to industrialized populations.