Author

M. Osawa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Pharmacology & Toxicology· 2 Biophysics· 1 Cancer Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

K. Saito· 2 shared M. K. Saito· 2 shared Y. Kawasaki· 2 shared A. Morita· 1 shared A. Teranishi· 1 shared C. Q. Vu· 1 shared E. B. Lane· 1 shared E. Hiejima· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersPharmacology & Toxicology

K. Saito

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Paroxetine-induced transient apoptosis with delayed neurogenesis induces brain remodeling in developing zebrafish

T. Sato, K. Saito, T. Oyu, K. Yamaguchi, M. Osawa, Y. Shiko, Y. Kawasaki, T. Kurisaki, S. Tsuda, T. Kajihara, M. Nagashima

This study shows that early paroxetine exposure in zebrafish embryos causes transient apoptosis, delayed neurogenesis, and brain remodeling linked to ASD-like social behavior impairments.

bioRxiv · Nov 10, 2023 · PreprintPharmacology & Toxicology

qMaLioffG: A single green fluorescent protein FLIM indicator enabling quantitative imaging of endogenous ATP

S. Arai, H. Itoh, C. Q. Vu, M. Nakayama, M. Oshima, A. Morita, K. Okamoto, S. Okuda, A. Teranishi, M. Osawa, Y. Tamura, S. Nonoyama, M. Takuma, T. Fujie, S. R. Sarker, , T. Kitaguchi

The paper introduces qMaLioffG, a green fluorescent protein FLIM indicator that quantitatively measures endogenous ATP levels by detecting fluorescence lifetime changes in physiological ATP concentrations.

bioRxiv · Aug 29, 2023 · PreprintBiophysics

Prediction of broad chemical toxicities using induced pluripotent stem cells and gene networks by transfer learning from embryonic stem cell data

J. Yamane, T. Wada, H. Otsuki, K. Inomata, M. Suzuki, T. Hisaki, S. Sekine, H. Kouzuki, K. Kobayashi, H. Sone, J. K. Yamashita, M. Osawa, M. K. Saito, W. Fujibuchi

This paper predicts chemical toxicities using induced pluripotent stem cells and gene networks via transfer learning from embryonic stem cell data, achieving high accuracy across multiple toxicity categories.

bioRxiv · Nov 5, 2021 · PreprintPharmacology & Toxicology

Aberrant localization of CDC42 C-terminal variants to the Golgi apparatus drives pyrin inflammasome-dependent autoinflammation

M. Nishitani-Isa, K. Mukai, Y. Honda, H. Nihira, H. Shibata, T. Tanaka, K. Kodama, E. Hiejima, K. Izawa, Y. Kawasaki, M. Osawa, Y. Katata, S. Onodera, T. Watanabe, S. Kure, , T. Yasumi

This study identifies that CDC42 C-terminal variants cause aberrant Golgi localization, leading to pyrin inflammasome activation and autoinflammation.

bioRxiv · Sep 3, 2021Immunology

Comparative analysis of antigen-specific anti-SARS-CoV-2 antibody isotypes in COVID-19 patients

H. Fujigaki, M. Inaba, M. Osawa, S. Moriyama, Y. Takahashi, T. Suzuki, K. Yamase, Y. Yoshida, Y. Yagura, T. Oyamada, M. Takemura, Y. Doi, K. Saito

This study compares antigen-specific antibody isotypes in COVID-19 patients to assess their kinetics, sensitivity, specificity, and correlation with neutralizing activity.

bioRxiv · Dec 4, 2020Immunology

Circumstances and factors of sleep-related sudden infant deaths in Japan

M. Osawa, Y. Ueno, N. Ikeda, K. Ikematsu, T. Yamamoto, W. Irie, S. Kozawa, H. Kotani, H. Hamayasu, T. Murase, K. Shingu, M. Sugimoto, R. Nagao, Y. Kakimoto

This study investigates recent trends and risk factors of sleep-related sudden infant deaths in Japan, identifying high odds ratios for teenage mothers and later birth order.

bioRxiv · May 4, 2020Pathology

A repetitive mutation and selection system for bacterial evolution to increase the specific affinity to pancreatic cancer cells.

M. Osawa

This study evolves bacteria to increase their specific binding to pancreatic cancer cells through mutation and selection, finding enhanced affinity for cancer cells over normal cells.

bioRxiv · Nov 10, 2017Cancer Biology