T. Izumi

Evaluating HIV Infectivity and Virion Maturation Across Varied Producer Cells with a Novel FRET-Based Detection and Quantification Assay

This study compares HIV-1 virion maturation and infectivity between Jurkat and HEK293T cells using a FRET-based assay, finding lower maturation and infectivity in Jurkat-derived virions.

NEDD4-binding protein 1 suppresses HBV replication by degrading HBV RNAs

This paper identifies N4BP1 as a host factor that suppresses HBV replication by degrading HBV RNAs, with its KH-like and RNase domains required for this effect.

Conserved cysteine residues in Kaposi's sarcoma herpesvirus ORF34 are necessary for viral production and viral pre-initiation complex formation.

This study identifies four conserved cysteine residues in KSHV ORF34 essential for vPIC formation and viral production through alanine-scanning mutants and structural modeling.

Functional hierarchy among different Rab27 effectors involved in secretory granule exocytosis

The paper investigates the functional hierarchy of Rab27 effectors in insulin secretion by comparing exocytic phenotypes in beta cells lacking different combinations of effectors.

Various miRNAs are involved in efficient HCV replication

This study identifies miRNAs other than miR-122 that support HCV replication in non-hepatic cells by interacting with the viral 5UTR and stabilizing the IRES structure.

Visualizing ATP Dynamics in Live Mice

The paper develops a transgenic mouse model with GO-ATeam to measure ATP dynamics in real-time across multiple organs and conditions, providing insights into ATP's role in physiology and disease.

Kaposi’s sarcoma-associated herpesvirus ORF66 is essential for late gene expression and virus production via interaction with ORF34

This study identifies ORF66's critical role in KSHV late gene expression and viral production by interacting with ORF34 and binding to the K8.1 promoter.

Extracellular matrix mineralization in the mouse osteoblast-like cell line MC3T3-E1 is regulated by actin cytoskeleton reorganization and non-protein molecules secreted from the cells themselves

This study shows that actin cytoskeleton reorganization and non-protein molecules secreted by MC3T3-E1 cells regulate extracellular matrix mineralization during osteoblast differentiation.