K. Patel

The paper identifies leukemia stemness and co-occurring mutations as drivers of resistance to IDH inhibitors in AML through genomic analyses of treated patients.

The paper identifies cellular and temporal factors associated with bacterial control in tuberculosis granulomas using multimodal data.

The paper determines the structure of the ANTAR domain protein EutV bound to an RNA target, revealing a single hexaloop binding mode and redefining the minimal binding motif.

This study examines clinicopathologic features and treatment outcomes in 65 patients with atypical chronic myeloid leukemia, identifying key mutations and predictors of survival.

This study shows that SF3B1 mutations specifically at codon K700E, but not other codons, are independently linked to better overall survival in myelodysplastic syndromes.

This study shows that wild-type p53 amyloid formation leads to cellular transformation and tumor formation in mice by enhancing survival, proliferation, and migration while suppressing tumor suppressors.

This study uses single-cell DNA sequencing to analyze clonal diversity in AML, revealing mutation co-occurrence, mutual exclusivity, and evolutionary patterns linked to treatment resistance and poor prognosis.

ShearFAST is a smartphone app that measures fluid shear stress in cell rockers, validated against motion tracking systems with high correlation.

The paper identifies high-affinity, specific cyclic peptide inhibitors of BET bromodomains using RaPID screening, revealing diverse binding modes and structures.

The paper investigates how visual and lateral line senses contribute to hunting in Astyanax mexicanus larvae raised in different light conditions, finding that all larvae rely on the lateral line, with dark-raised surface fish showing greater dependence.

The paper assesses how human activity affects genetic connectivity in four Indian mammals, finding species-specific impacts of landscape features on gene flow.

This study investigates age-related changes in skeletal muscle by examining SULF1/SULF2 and RTK/Wnt signalling components, showing their reduced expression and impact on satellite cell function in aged mice.

This study investigates the mechanism of CHD4-mediated nucleosome sliding using single-molecule assays, revealing a decoupling of DNA translocation at entry and exit sides.

This study identifies differentially expressed long non-coding RNAs in early-stage breast cancer and evaluates their prognostic significance using RNA sequencing and TCGA datasets.

This study shows ELF3 suppresses epithelial-mesenchymal transition in bladder cancer by reducing mesenchymal markers and invasion.