K. Zhang

This study identifies the Sam50-Mic19-Mic60 axis as critical for mitochondrial cristae architecture by connecting SAM and MICOS complexes through OMA1-mediated cleavage of Mic19.

The paper identifies an immune signature in invasive ductal carcinoma that predicts prognosis and response to immunotherapy.

This study shows that low concentrations of melatonin promote cotton seed germination by enhancing antioxidant enzyme activity, reducing MDA, and modulating plant hormones like ABA and GA3.

The paper develops a method to predict RNA secondary structure using chemical shifts, achieving accurate predictions for 108 RNAs and confirming conditional prediction of miR-20b structures.

This study identifies two regions on MiD51 that bind Drp1 and shows that MiD51 dimerization via a disulfide bond is required for Drp1 recruitment, revealing a multi-faceted regulatory mechanism for mitochondrial fission.

This study shows that HPV16 regulates SAMHD1 expression in oral keratinocytes, and SAMHD1 deletion enhances viral replication and cell proliferation in HPV16-infected cells.

This study shows low-dose IFN-γ promotes tumor stemness in NSCLC via ICAM1-PI3K-Akt-Notch1 pathway, while high-dose IFN-γ induces apoptosis through JAK1-STAT1-caspase pathway.

The paper develops a microchip-based sequential secretion assay to analyze protein dynamics in single human macrophages, revealing distinct activation modes and states dependent on basal conditions.

This study examines the cellular immune response of Oxya chinensis to bacterial infections, identifying plasmatocytes and granulocytes as key phagocytic cells.

scFTD-seq enables high-quality single-cell 3' mRNA profiling using freeze-thaw lysis, offering a portable and flexible workflow for distributed sample processing.

The paper introduces an M-value to quantify mitochondria-lysosome contact and mitophagy using structured illumination microscopy, finding distinct M-value ranges for these processes.

This study identifies herpesvirus protein kinases that phosphorylate SAMHD1 to inhibit its dNTPase activity, thereby evading host antiviral defenses.

This study uses a microvasculature-on-a-chip system to analyze ex vivo dynamics of human glioblastoma cells, showing correlations with tumor heterogeneity and subtypes.

This study shows autophagy promotes osimertinib resistance in EGFR-mutant lung cancer by enhancing stem-cell like properties, and inhibiting autophagy reverses resistance.

This study evaluates fusidic acid and its hydrogenation derivative for antimicrobial and anti-inflammatory effects against Gram-positive bacteria and in a mouse model.

This study differentiates dermal mesenchymal stem cells into vascular endothelial cells using endothelial cell line conditioned medium, showing high CD31 expression and angiogenic ability.

This paper uses persistent homology to analyze leaf shapes from 182,707 leaves across 141 plant families, revealing phylogenetic and geographic differences in leaf morphology.