L. Shi

This study examines the bioaccumulation and immune response of sea cucumbers exposed to chronic dietary hexavalent chromium, finding tissue-specific accumulation and altered enzyme activities.

This study identifies the EMC complex's role in regulating intestinal stem cell proliferation via the Hippo pathway in Drosophila, showing its negative regulation and evolutionary conservation.

This study identifies ACE2 as the receptor for NeoCoV and PDF-2180-CoV, two close MERS-CoV relatives in bats, showing they can use bat ACE2 and, with mutation, human ACE2.

This study identifies glutamine as essential for M1-like macrophage polarization during Mycobacterium tuberculosis infection through metabolic reprogramming involving the TCA cycle and biosynthesis of signaling molecules and antimicrobial metabolites.

This study shows that histone neutralization with STC3141 reduces circulating histones, improves oxygenation, and decreases lung edema in a rat model of LPS-induced ALI, similar to dexamethasone.

The paper shows that neural stemness unifies tumorigenicity and pluripotent differentiation potential by demonstrating SETDB1's role in maintaining these properties through epigenetic and transcriptional mechanisms.

The paper reports the 3.9 Å resolution structure of the Arabidopsis thaliana NDH-PSI supercomplex, revealing its assembly and interactions.

This study shows boron alleviates aluminum toxicity in Arabidopsis roots by restoring PIN2 endocytosis and auxin transport, reversing auxin depletion in the elongation zone.

This study shows RAD51 forms distinctive nuclear zones to facilitate homologous recombination by bridging damaged and intact DNA during repair.

This paper develops an immunocompetent ER+ breast cancer mouse model with spontaneous bone metastasis and antiestrogen responsiveness, showing treatment efficacy with tamoxifen and fulvestrant.

This study demonstrates retron editing enables efficient precise genome editing in human cells without exogenous donor DNA, achieving up to 10% editing rates at endogenous loci.

This study produces and tests virus-free CRISPR-CAR T cells that effectively regress solid tumors in vivo.

This study shows SIRPα enhances IL-4/13 signaling in macrophages by sequestering SHP-2, promoting alternative activation and immunosuppression.

This study demonstrates that S309-CAR-NK cells effectively target and kill SARS-CoV-2-infected cells, including the D614G mutant, outperforming CR3022-CAR-NK cells in vitro.

The paper identifies lncEry, a long non-coding RNA that regulates mouse erythroid differentiation and maturation by interacting with WDR82 to control Klf1 and globin gene transcription.

This study shows that inhibiting AHR signaling enhances terminal differentiation of human erythrocytes by promoting F-actin remodeling and cytoskeleton maturation.

This study shows that biomechanical properties of the limbal niche regulate YAP activity, which is essential for maintaining stemness and regeneration in corneal epithelial stem cells.

This study identifies FFPE processing errors in oncology panel sequencing by analyzing variants from technical artifacts in FFPE samples with varying fixation times and block positions.

The paper develops a computational method to predict ER retention sequences that can undergo secretion during ER calcium depletion by analyzing non-canonical ERS sequences.

This study reports the crystal structures and biochemical characterization of SOQ1 lumenal domains, revealing their structural organization and potential regulatory mechanisms in suppressing qH.

The paper uses single-cell RNA analysis to compare immune cell profiles in young and old mice, finding higher proportions of effector cells in old mice that may enhance tumor defense.

This paper identifies platelet RNAs that predict occult tumor progression in a mouse melanoma model, showing high diagnostic accuracy for early cancer detection.

This study shows CD117/c-kit expression in prostate cancer cells correlates with poor survival and promotes aggressiveness, migration, and TKI resistance through CSC-like properties.

The paper shows PRMT1 maintains neural stemness by coordinating ribosomes and proteasomes through arginine methylation, preventing degradation and supporting protein homeostasis in cancer and neural stem cells.

This study identifies immune mechanisms underlying CyHV-3 resistance in a common carp strain through transcriptomic analysis of gene and lncRNA expression.

This study shows that miRNA-223 inhibits gallstone formation in mice by targeting ABCG5 and ABCG8, key transporters in the bile cholesterol secretion pathway.

The paper shows that β-Amyloid peptides modulate the switching behavior of donor-acceptor Stenhouse adducts, reducing molecular switching rates and inhibiting aggregation.

This study uses proteomics to identify down-regulated ECM proteins in guinea pig cochleae after noise exposure, linking them to hearing loss mechanisms.

This study analyzes immune responses in COVID-19 patients using single-cell RNA sequencing to identify differences in immune cell behavior across disease severity stages.

This paper creates a single-cell transcriptomic atlas of the Chinese horseshoe bat to study its role as a viral reservoir, identifying cell types and receptor expression patterns related to viral entry.