L. Yao

This study introduces a multi-enzyme directed evolution model to improve screening throughput and efficiency, revealing convergent evolution in two cytochrome P450 enzymes with distinct active sites achieving similar functions.

The paper introduces WIAD, an open-source tool for visual analysis of wood images to improve transparency and reproducibility in ecological studies.

IBEX enables high-resolution, multi-plex imaging of over 65 parameters in tissue sections without degradation, supporting spatial analysis and integration with other technologies.

The paper profiles longitudinal single-cell immune responses in asymptomatic COVID-19 patients and identifies distinct innate immune features associated with asymptomatic disease.

This study shows that changes in hydrogen bonding near the S3 subsite of caspase-3 affect P4 amino acid selection, leading to relaxed specificity in zebrafish caspase-3a compared to caspase-6.

This study identifies marrow adipogenic lineage precursors (MALPs) as critical regulators of osteoclastogenesis through RANKL expression, showing their role in both normal bone remodeling and pathologic bone loss.

This study shows that metformin chlorination byproducts are toxic to nematodes, human cells, and mice, and identifies boiling and activated carbon as effective removal methods.

The paper identifies RPS15 as an antimicrobial peptide with conserved antibacterial activity across species, showing it can kill bacteria through membrane disruption and ROS induction.

This study shows NDRG2 maintains intestinal epithelial barriers by regulating E-cadherin and adherens junctions, preventing colitis and tumor development.

The paper uses CRISPRi screening in Synechocystis to identify gene targets that enhance growth, lactate tolerance, and chemical production.

The paper identifies a unique adipocyte population in bone marrow, MERAs, that regulate bone and vessel homeostasis through single-cell transcriptomics in mice.

This study develops a covalent inhibitor of gut bacterial bile salt hydrolases, showing it reduces BSH activity and deconjugated bile acids in mice.

This study identifies key gut bacteria correlated with systemic iron levels using a murine model and bioinformatic tools, establishing a non-invasive prediction model for iron-related diseases.

The paper assesses H. pylori stool shedding and cagA genotype in gastric cancer patients and non-cancer controls, finding higher stool shedding and association with the East Asian cagA allele.