C. Huttenhower

Discovering and exploring the hidden diversity of human gut viruses using highly enriched virome samples

The paper presents a method to discover new human gut viruses using enriched virome samples and reports over 162,000 novel viral sequences.

Gut-resident microorganisms and their genes are associated with cognition and neuroanatomy in children

This study links gut microbiota composition and gene functions to cognitive function and brain structure in children using machine learning models.

Identification and targeting of microbial putrescine acetylation in bloodstream infections

The paper identifies bacterially-derived N-acetylputrescine as a marker of severe gram-negative bloodstream infections and shows that inhibiting its synthesis reduces bacterial growth and antibiotic resistance.

Human threat learning is associated with gut microbiota composition

The paper investigates the relationship between gut microbiota composition and threat learning in humans, finding that threat learning varies with microbiome composition while safety learning does not.

{-}Multivariable Association Discovery in Population-scale Meta-omics Studies

This paper introduces MaAsLin 2, a method for analyzing multivariable associations in microbial multi-omics data, and applies it to reveal new insights into inflammatory bowel disease.

Human gut bacteria produce TH17-modulating bile acid metabolites

This study identifies human gut bacteria that produce TH17-modulating bile acid metabolites, showing reduced levels in IBD patients.

A Bacterial Bile Acid Metabolite Modulates Treg Activity through the Nuclear Hormone Receptor NR4A1

This study identifies a bacterial bile acid metabolite, isoalloLCA, that enhances Treg cell differentiation via NR4A1 and is reduced in inflammatory bowel disease patients.

Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3

The paper introduces bioBakery 3, a set of tools for microbial community analysis, improving taxonomic, functional, and strain-level profiling with applications to CRC and IBD datasets.

Delivery mode impacts newborn gut colonization efficiency

This study investigates how delivery mode affects newborn gut microbiome colonization, finding that C-section infants lack Bacteroides species, but these are not due to birth canal exposure.

The Prevotella copri complex comprises four distinct clades that are underrepresented in Westernised populations

The study identifies four distinct clades within the Prevotella copri complex, showing reduced prevalence in Westernised populations compared to non-Westernised ones.

American Gut: an Open Platform for Citizen-Science Microbiome Research

The paper uses citizen-science data to analyze human stool microbiomes, revealing new insights into microbial diversity, metabolome composition, and associations with diet and health.