M. Hu

This paper develops a microfluidic assay to directly measure antibody affinity and concentration in solution, applied to characterise alloantibody-HLA interactions in transplant patient sera.

The paper shows how cell shape changes affect subcellular organelle positioning, altering Ca2+ signaling and phenotypic function in vascular smooth muscle cells.

This paper introduces statistical measures for spatial rotations and projection directions in cryoEM, accounting for molecular symmetry, and implements them in an open-source Python package.

The paper investigates whether pre-existing cutaneous conditions increase SARS-CoV-2 infection risk by examining ACE2 expression and skin barrier function in human and mouse models.

This study develops a computational strategy for in silico nanobody affinity maturation, achieving a 17.5-fold improvement in binding affinity for an anti-HIF-1α nanobody.

The paper identifies FCHSD2 as a new regulator of insulin secretion by analyzing 3D chromatin interactions at the STARD10 locus in human islets.

This study examines risperidone-induced DNA methylation changes in first-episode schizophrenia patients and links them to neuroimaging and cognitive phenotypes.

This study investigates how maternal hyperandrogenism and insulin resistance in pregnant rats affect ferroptosis in uterine and placental tissues, revealing differential molecular and cellular mechanisms.

The paper identifies a 22-gene expression signature to measure glycolysis activity across 25 cancer types, showing its correlation with hypoxia, genomic instability, and tumor proliferation.

The paper identifies RGS1 as a marker and promoter of T cell exhaustion in multiple cancers using single-cell transcriptome analysis and validates its association with poor prognosis.

The paper develops a method to measure multiscale chromatin folding and nuclear structures in single cells, revealing cell-type-specific architectures and physical principles of chromatin organization.

This study uses single-cell RNA sequencing to identify an endosymbiotic cell type in a soft coral and reveals its lineage dynamics during algal uptake and maintenance.

This study investigates how temperature affects Legionella pneumophila growth in a lab-scale cooling tower, its protozoan hosts, and microbial diversity in biofilms.

The paper uses CRISPR-Cas9 screens in isogenic ccRCC cell lines to identify synthetic lethal partners of VHL, revealing new therapeutic targets for renal cell carcinoma.

The paper reports the cryo-EM structure of tetrameric Ptch1 bound to ShhNp, revealing an asymmetric mechanism of Hh ligand inhibition.

This study shows metformin improves uterine progesterone signaling in PCOS-like rats by reducing PGR and ER expression and correcting gene expression abnormalities.