M. Kumar

Adhatoda Vasica ameliorates cellular hypoxia dependent mitochondrial dysfunction in acute and severe asthmatic mice.

This study shows Adhatoda Vasica extract reduces hypoxia-induced mitochondrial dysfunction and inflammation in asthma models, offering potential for treating severe steroid-resistant asthma.

ATM-deficient lung, prostate and pancreatic cancer cells are acutely sensitive to the combination of olaparib and the ATR inhibitor AZD6738

This study shows that ATM-deficient cancer cells are more sensitive to the combination of olaparib and AZD6738, leading to cell death.

Human Telomerase Expression is under Direct Transcriptional Control of the Telomere-binding-factor TRF2

This study shows TRF2 directly represses hTERT through G-quadruplex-dependent mechanisms, linking telomere regulation to telomerase activity in normal and cancer cells.

The conformational and mutational landscape of the ubiquitin-like marker for the autophagosome formation in cancer

The paper evaluates molecular dynamics models of LC3B and analyzes 26 missense mutations to understand their impact on structure and function in cancer.

Activation of Multiple Signalling Pathways by P152Lp53 Mutant Reveals New Gain-of-function Implicating Tumorigenesis

This study identifies P152Lp53 as a gain-of-function mutant that promotes cell mobility, proliferation, invasion, and tumorigenesis through upregulated signalling pathways.

MS Western, a method of multiplexed absolute protein quantification is a practical alternative to western blotting

MS Western provides a method for absolute protein quantification without antibodies or labels, outperforming Western blotting in specificity and sensitivity.

A high-throughput assay to identify robust inhibitors of dynamin GTPase activity

The paper develops a sensitive fluorescence assay to identify dynamin GTPase inhibitors and finds that existing compounds like Dynasore and Dyngo-4a do not inhibit basal activity.

AspWood: High-spatial-resolution transcriptome profiles reveal uncharacterized modularity of wood formation in Populus tremula

The paper generates high-spatial-resolution transcriptome data from Populus tremula wood-forming tissues and identifies novel gene modules and expression patterns involved in cambial growth and wood formation.