M. Kumar

Integration of synthetic microbial consortia based bioprocessing with pyrolysis for efficient conversion of cellulose to valuables

This paper integrates synthetic microbial consortia-based bioprocessing with pyrolysis to convert cellulose into chemicals and biofuels, achieving high product yields.

FAK drives resistance to therapy in HPV-negative head and neck cancer in a p53-dependent manner.

This study identifies FAK as a driver of therapy resistance in HPV-negative HNSCC, showing its role is dependent on mutant TP53.

An intranasal nanoparticle STING agonist has broad protective immunity against respiratory viruses and variants

This study develops NanoSTING, an intranasal nanoparticle STING agonist, showing broad protection against respiratory viruses and variants in animal models.

Stepwise origin and evolution of a transcriptional activator and repressor system integrating nutrient signaling in plants

This study identifies the stepwise origin and evolution of a transcriptional activator-repressor system in plants through evolutionary analysis and phylogenetic reconstruction.

Differential pathogenesis of SARS-CoV-2 variants of concern in human ACE2-expressing mice

This study compares the pathogenesis of SARS-CoV-2 variants in human ACE2-expressing mice, finding that some variants are more lethal and replicate more in the lungs and brain.

Remdesivir, Zidovudine (AZT) and Nevirapine inhibit Chandipura virus replication through high energy interactions with the RdRp domain of the polymerase protein L

This study investigates the antiviral effects of remdesivir, nevirapine, and AZT on Chandipura virus replication and identifies remdesivir as the most potent inhibitor through molecular docking analysis.

Knockout of Sorbs2 in Cardiomyocytes Leads to Dilated Cardiomyopathy in Mice

This study shows that deleting Sorbs2 in cardiomyocytes causes dilated cardiomyopathy in mice, with defects in microtubule polymerization and structural proteins, and links Sorbs2 variants to human cardiac diseases.

Influenza virus-like particle-based hybrid vaccine containing RBD induces immunity against influenza and SARS-CoV-2 viruses

This study develops a hybrid vaccine combining influenza VLPs with SARS-CoV-2 RBD and GM-CSF, showing protection against both viruses in mice.

Insights into the Human Gut Virome by Sampling a Population from the Indian Subcontinent

This study analyzes the gut virome of an Indian population using metagenomics, identifying novel viral families and a core virome composition.

Inactivation mechanism and efficacy of grape seed extract for Human Norovirus surrogate

This paper shows grape seed extract (GSE) is more effective than chemical disinfectants at inactivating Tulane virus, a human norovirus surrogate, by causing virus aggregation.

Quinacrine binds to the kinase domain of FGFR1 and inhibits its activity

This study shows quinacrine binds to FGFR1's kinase domain, inhibits its activity, and reduces phosphorylation, proliferation, and migration in cancer cells.

Waning grasslands: a quantitative temporal evaluation of the grassland habitats across human-dominated upper Gangetic Plains, north India

The paper quantitatively assesses the decline of grassland habitats in the upper Gangetic Plains over 30 years, finding a 57% reduction mainly due to conversion to croplands.

SARS-CoV-2 variants of concern infect the respiratory tract and induce inflammatory response in wild-type laboratory mice

This study infects wild-type mice with SARS-CoV-2 variants to show B.1.1.7 and B.1.351 replicate more efficiently and induce stronger inflammatory responses than the original B.1 virus.

Dissection of function and recognition mechanism of M. tuberculosis ESX-1 secreted virulence factor EspC

The paper investigates the function and recognition mechanism of M. tuberculosis ESX-1 virulence factor EspC and its interaction with EccA1 ATPase, identifying key binding regions and their impact on secretion.

Engineering large-scale perfused tissues via synthetic 3D soft microfluidics

This paper develops a synthetic 3D microfluidic platform to perfuse large engineered tissues, demonstrating viability and accelerated neural differentiation in perfused constructs.

Artemisinin acts by inhibiting Plasmodium falciparum Ddi1, a retropepsin, resulting into the accumulation of ubiquitinated proteins

This study shows that Artemisinin inhibits Plasmodium falciparum Ddi1, leading to ubiquitinated protein accumulation and impaired damage recovery.

In-vitro Reconstitution of Membrane Contact Sites between the Endoplasmic Reticulum and Lipid Droplets

This study reconstitutes MCS between ER and lipid droplets in vitro, showing Rab18 and phosphatidic acid regulate MCS formation in response to metabolic and immune signals.

ErpY-like lipoprotein of Leptospira outsmart host complement regulation by acquiring complement regulators, activating alternate pathway, and intervening membrane attack complex

This study shows that the ErpY-like lipoprotein of Leptospira binds complement regulators, activates the alternate pathway, and reduces membrane attack complex deposition, aiding immune evasion.

Histopathological Study Of Different Organs Of Charles Foster Rats Under The Exposure Of Pueraria tuberosa

The study evaluates the safety of Pueraria tuberosa water extract on rat organs, finding no adverse effects at certain doses over specific periods.

Effective Therapy Targeting Cytochrome bc1 Prevents Babesia Erythrocytic Development and Protects from Lethal Infection

This study identifies an effective ELQ prodrug that prevents Babesia erythrocytic development and protects against lethal infection in mouse models.

The Sugar Porter gene family of Piriformospora indica: Nomenclature, Transcript Profiling and Characterization

The paper identifies and characterizes 19 hexose transporters in Piriformospora indica, showing differential expression under various nutrient conditions and functional roles in carbohydrate uptake.

Targeting the artemisinin resistant malaria by repositioning of the anti-Hepatitis C Virus drug Alisporivir

This study repositions Alisporivir, an anti-Hepatitis C drug, as a potential treatment for artemisinin-resistant malaria by targeting PfCyP-19B, which is overexpressed in resistant parasites.

Neuroinvasion and encephalitis following intranasal inoculation of SARS-CoV-2 in K18-hACE2 mice

This study shows that SARS-CoV-2 causes neuroinvasion and encephalitis in K18-hACE2 mice, leading to 100% mortality by day 6 post-infection.

A Novel Class of Azoles with potent Anti-Leishmanial activity

The paper screens a novel azole library against Leishmania donovani to identify potent anti-leishmanial compounds.

RNA binding of Hfq monomers promotes RelA-mediated hexamerization in a limiting Hfq environment

This study shows that RelA-mediated Hfq hexamerization requires RNA binding to Hfq monomers, challenging the idea that only hexamers can bind RNA.

ADEP1 activated ClpP1P2 macromolecule of Leptospira, an ideal Achilles' heel to deregulate proteostasis and hamper the cell survival

This study shows ADEP1 activates Leptospira ClpP1P2, disrupting proteostasis and inhibiting growth by altering peptidase activity and enabling proteolytic degradation of unfolded proteins.

Molecular Determinants of Prognosis and Evolution in Diffuse-Lower Grade Astrocytomas

This study identifies PDGF pathway activation as a key driver of rapid progression in IDH wild-type low-grade astrocytomas compared to mutant tumors.

The FDA-approved gold drug Auranofin inhibits novel coronavirus (SARS-COV-2) replication and attenuates inflammation in human cells

This study shows that auranofin inhibits SARS-CoV-2 replication and reduces inflammation in human cells, suggesting its potential as a therapeutic option for COVID-19.

An atlas of Arabidopsis protein S-Acylation reveals its widespread role in plant cell organisation of and function.

This study creates an atlas of S-acylation in Arabidopsis, identifying 5185 modified cysteines across 2643 proteins, highlighting its role in plant cell function and cellulose synthesis.

Inhibition of histone acetyltranserase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a novel gain of function.

The paper identifies CREBBP/EP300 as radiosensitization targets in mutant tumors by inhibiting histone acetyltransferase, which represses homologous recombination and increases radiation sensitivity.