Author

J. C. Sun

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:statistical model· 2

Frequent Co-Authors

S. Grassmann· 3 shared C. M. Lau· 2 shared E. K. Santosa· 2 shared A. H. Settle· 1 shared A. M. Mujal· 1 shared A. Straub· 1 shared B. Y. Winer· 1 shared C. S. Leslie· 1 shared

Activity by Year

2021-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersImmunology

S. Grassmann

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Author profile →

6 papers

Recent·Most cited

Step-wise epigenetic signal integration governs adaptive programming of cytotoxic lymphocytes

S. Grassmann, E. K. Santosa, H. Kim, I. B. Johnson, A. M. Mujal, J.-B. LeLuduec, S. X. Fan, M. Owyong, A. Straub, L. Deng, C. M. Lau, K. Hsu, D. Busch, J. C. Sun

This study shows that interleukin-12 signaling integrates with antigen receptor signals in a context-dependent manner to determine the epigenetic and functional fate of cytotoxic lymphocytes.

bioRxiv · Nov 7, 2023 · PreprintImmunology

Single-Cell Profiling Reveals a Naive-Memory Relationship between CD56bright and Adaptive Human Natural Killer Cells

M. K. Panjwani, S. Grassmann, R. Sottile, J.-B. Le Ludeuc, T. Kontopoulos, K. van der Ploeg, J. C. Sun, K. C. Hsu

The paper identifies a naive-memory relationship between CD56bright and adaptive human natural killer cells through phenotypic, transcriptional, and functional profiling.

bioRxiv · Sep 23, 2023 · PreprintImmunology

Clonal stochasticity in early NK cell response to mouse cytomegalovirus is generated by mature subsets of varying proliferative ability

D. Wethington, S. Ahmad, M. Potempa, G. Giuliani, O. A. Aguilar, M. Poudel, S. Grassmann, W. Stewart, N. M. Adams, J. C. Sun, L. L. Lanier, J. Das

This study quantifies how clonal stochasticity in NK cell responses to MCMV arises from proliferation and death dynamics of mature NK subsets.

bioRxiv · Sep 7, 2023Immunology

Topographical analysis of immune cell interactions reveals a biomechanical signature for immune cytolysis

M. de Jesus, A. H. Settle, D. Vorselen, T. K. Gaetjens, M. Galiano, Y. Y. Wong, T.-M. Fu, E. Santosa, B. Y. Winer, F. Tamzalit, M. S. Wang, Z. Bao, J. C. Sun, P. Shah, J. A. Theriot, , M. Huse

The paper analyzes immune cell interactions using traction force microscopy to identify biomechanical features associated with cytotoxic T cell activity.

bioRxiv · Apr 16, 2023 · PreprintImmunology

3D Chromatin Dynamics during Innate and Adaptive Immune Memory Acquisition

E. K. Santosa, C. M. Lau, M. Sahin, C. S. Leslie, J. C. Sun

This study investigates 1D and 3D chromatin dynamics during immune memory formation in innate and adaptive lymphocytes using histone profiling, ATAC-seq, RNA-seq, and HiC.

bioRxiv · Jan 16, 2023 · PreprintImmunology

The RNA m6A reader YTHDF2 controls NK cell anti-tumor and anti-viral immunity

S. Ma, J. Yan, T. Barr, J. Zhang, Z. Chen, L.-S. Wang, J. C. Sun, J. Chen, M. A. Caligiuri, J. Yu

This study shows YTHDF2, an m6A reader, enhances NK cell anti-tumor and anti-viral responses by regulating homeostasis, maturation, and effector function through STAT5 feedback and Tardbp interactions.

bioRxiv · Apr 26, 2021Immunology