Author

M. T. Hemann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:CRISPR screen· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

D. A. Lauffenburger· 2 shared A. A. Lane· 1 shared A. B. Miller· 1 shared A. Langenbucher· 1 shared A. Luengo· 1 shared A. N. Lau· 1 shared A. Q. Zhang· 1 shared A. Ramos· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersImmunology

D. A. Lauffenburger

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Author profile →

4 papers

Recent·Most cited

Functional genomics reveals an off-target dependency of drug synergy in gastric cancer therapy

O. Leylek, M. E. Honeywell, M. J. Lee, M. T. Hemann, G. Ozcan

The paper identifies an off-target dependency of erlotinib in enhancing SN38's synergistic effect in gastric cancer through functional genomics.

bioRxiv · Oct 7, 2023Cancer Biology

Leukemia circulation kinetics revealed through blood exchange method

A. B. Miller, A. Langenbucher, F. H. Rodriguez, L. Lin, C. Bray, S. Duquette, Y. Zhang, D. Goulet, A. A. Lane, D. M. Weinstock, M. T. Hemann, S. R. Manalis

This study uses a blood exchange method in mouse leukemia models to show that leukemia cells circulate longer than solid tumor cells and that microenvironmental factors like E-selectin influence their clearance.

bioRxiv · Sep 3, 2023Cancer Biology

CARPOOL: A library-based platform to rapidly identify next generation chimeric antigen receptors

T. Kyung, K. S. Gordon, C. R. Perez, P. V. Holec, A. Ramos, A. Q. Zhang, Y. Liu, C. Koch, A. Starchenko, B. Joughin, D. A. Lauffenburger, D. J. Irvine, M. T. Hemann, M. E. Birnbaum

The paper develops a library-based platform to identify optimized chimeric antigen receptors (CARs) with improved anti-tumor functions through high-throughput screening of diverse signaling domains.

bioRxiv · Jul 9, 2021Immunology

Pancreatic Stellate Cells Secrete Deoxycytidine Conferring Resistance to Gemcitabine in PDAC

S. Dalin, M. R. Sullivan, E. Kreidl, A. N. Lau, B. Grauman-Boss, S. Fenoglio, A. Luengo, M. G. Vander Heiden, D. A. Lauffenburger, M. T. Hemann

This study shows that pancreatic stellate cells secrete deoxycytidine, which reduces the effectiveness of gemcitabine in PDAC by inhibiting its processing in cancer cells.

Cancer Research · Nov 15, 2019Peer-reviewedCancer Biology