M. Zhou

The paper reports the structure of human ferroportin complexed with minihepcidin PR73, revealing novel interactions that enhance inhibition potency compared to hepcidin.

The paper analyzes aging and cancer by profiling ubiquitinome and RNA-seq data in mice, identifying H2A ubiquitination as a marker linked to prognosis and tumor microenvironment.

The paper enhances DeepLabCut for multi-animal pose estimation and tracking by adding identity prediction and robust assembly features, validated on four benchmark datasets.

The paper reports the cryo-EM structure of artemin, revealing its intramolecular disulfide bond and C-terminal helix's role in dimer stabilization.

The paper reports the cryo-EM structure of eukaryotic GSIII from Ostreococcus tauri and shows it forms a single hexameric ring, differing from other GS classes.

This paper identifies a small-molecule antagonist targeting the Tudor domain of SMN, disrupting its interaction with RNAP II and mimicking SMN depletion effects.

The paper reports the structure of PepT1 from horse, showing the extracellular domain (ECD) interacts with TM1 and bridges N- and C-domains, with ECD deletion or mutations impairing transport activity.

The paper identifies 707 O-GlcNAcylated proteins in cardiac tissue during pressure overload hypertrophy, finding 233 significantly increased, with validation of CPT1B and PDH.

This study shows STEAP1 can support a cross-membrane electron transfer chain via FAD, and determines the structure of STEAP2 in complex with NADP+ and FAD.

The paper reports the structure and function of PurTCp, a NAT family transporter from Colwellia psychrerythraea, showing it transports purines via H+-dependent mechanism and identifies a critical aspartate residue.

This study identifies and validates multiple novel targets of HSV-1 ICP0 in neuronal cells using proteomic approaches and functional experiments, revealing potential restrictive activities of SNX9 and OTUD4.

This study analyzes C. gattii VGII isolates from China using MLST and WGS, revealing genetic diversity and virulence differences, with no drug resistance observed.

This study develops an intranasal vaccine against SARS-CoV-2 using an influenza virus vector and shows it provides rapid, prolonged, and broad protection against multiple variants in hamsters.

This study shows that cyt b5 reductase, cyt b5, and SCD1 form a stable ternary complex mediated by transmembrane helices, enhancing electron transfer rates.

This study shows that Pparg promotes luminal differentiation and tumor formation in urothelial cells, with tumors showing immune desertion and potential subtype shifts over time.

This study identifies Ceg3 as an ADP-ribosyltransferase that modifies host ADP/ATP translocases, impairing their function and modulating host energy metabolism to aid Legionella pneumophila survival.

This study uses a mitochondrial uncoupler to actively demethylate DNA in neuroblastoma cells, promoting differentiation and altering the epigenome.

This study identifies three FDA-approved drugs that inhibit Lujo virus entry by targeting the envelope glycoprotein's transmembrane domain and calcium channels.

The paper introduces DeepHoF, a deep learning method to predict viral hosts, and applies it to SARS-CoV-2 to identify potential hosts and analyze host range uniformity during the pandemic.

This study uses single-molecule techniques to show MukBEF, an E. coli SMC complex, slides DNA unidirectionally and regulates chromosome organization through ATP-dependent mechanisms.

This study investigates how retrocyclin-101 inhibits flavivirus infection by targeting the NS2B-NS3 protease and the DE loop of the E glycoprotein.

The paper develops a free-energy landscape model of the proteasome ATPase complex to reveal how ATP hydrolysis drives substrate translocation through cooperative subunit movements.

This study demonstrates that stem cell-derived secretome reduces intraocular pressure and protects retinal ganglion cells in glaucoma models through COX2-PGE2 pathway activation and extracellular matrix remodeling.

This study screens botanical drugs against SARS-CoV-2 entry and identifies four compounds that inhibit viral entry and show synergy with remdesivir.

This study uses fMOST and scRNA-seq to map the spatial and cellular distribution of rabies virus in the mouse brain, revealing infection in multiple nuclei and non-neuronal cells.

The paper develops a chemical probe, UNC6934, that targets the PWWP1 domain of NSD2, revealing cooperative control of NSD2 localization through chromatin reader domains.

The paper shows MatP and topoisomerase IV ParC compete for binding to the MukB dimerization hinge, with matS binding displacing MatP from the hinge.

This study identifies CLASSY1-4 as key regulators of tissue-specific DNA methylation in Arabidopsis, showing their role in shaping epigenetic diversity during development.