Maia Zethoven

Phylogenetic analysis of paired breast carcinomas identifies genetic events associated with clonal recurrence and invasive progression

The paper analyzes paired breast carcinomas to determine if recurrences are clonal or new tumors, finding 7% are non-clonal by whole exome sequencing.

Long-lived chondroprogenitors are generated by fetal-limb Gli1+ cells and are replenished upon mosaic cell-cycle arrest in the cartilage

The paper identifies Gli1+ cells as fetal precursors of long-lived cartilage progenitors and shows they can compensate for cell-cycle arrest in cartilage.

Disruption of metazoan gene regulatory networks in cancer alters the balance of co-expression between genes of unicellular and multicellular origins

The paper shows cancer disrupts gene regulatory networks by altering co-expression between genes of unicellular and multicellular origins, with changes more pronounced in advanced tumors.

A PP2A-Integrator complex fine-tunes transcription by opposing CDK9

The paper identifies a PP2A-Integrator complex that opposes CDK9 activity to regulate transcription and shows its therapeutic synergy in leukemia.