Author

Ming Jian Ge

Baylor College of Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:Drosophila· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:metabolomics· 1

Frequent Co-Authors

Hugo Jozef BelleniD· 3 shared Oguz KancaiD· 3 shared Zhongyuan ZuoiD· 3 shared Debdeep DuttaiD· 2 shared Jonathan D. ZiriniD· 2 shared Liwen Ma· 2 shared Norbert PerrimoniD· 2 shared Wen‐Wen LiniD· 2 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersNeuroscience

Hugo Jozef BellenORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Loss of Mitochondrial Enoyl CoA Reductase causes elevated ceramide levels and impairs iron metabolism

Debdeep Dutta, Oguz Kanca, Seul Kee Byeon, Paul C. Marcogliese, Zhongyuan Zuo, Rishi V. Shridharan, Jun Hyoung Park, Undiagnosed Diseases Network, Guang Lin, Ming Jian Ge, Gali Heimer, Jennefer N. Kohler, Matthew Thomas Wheeler, Benny Abraham Kaipparettu, Akhilesh Pandey, Hugo Jozef Bellen

This study shows that loss of MECR causes elevated ceramide levels and impaired iron metabolism, linking mitochondrial fatty acid synthesis to neurodegeneration.

bioRxiv · Apr 14, 2023 · PreprintNeuroscience

An expanded toolkit for Drosophila gene tagging using synthesized homology donor constructs for CRISPR mediated homologous recombination

Oguz Kanca, Jonathan D. Zirin, Yanhui Hu, Burak Tepe, Debdeep Dutta, Wen‐Wen Lin, Liwen Ma, Ming Jian Ge, Zhongyuan Zuo, Luping Liu, Robert W. Levis, Norbert Perrimon, Hugo Jozef Bellen

The paper develops new CRISPR-based constructs for Drosophila gene tagging, enabling efficient gene modification with a 70-80% success rate regardless of exon-intron structure.

eLife · Jun 20, 2022Peer-reviewedGenetics

An efficient CRISPR-based strategy to insert small and large fragments of DNA using short homology arms

Oguz Kanca, Jonathan D. Zirin, Jorge García‐Marqués, Shannon M. Knight, Donghui Yang‐Zhou, Gabriel O. Amador, Hyung-Lok Chung, Zhongyuan Zuo, Liwen Ma, Yuchun He, Wen‐Wen Lin, Yīng Fāng, Ming Jian Ge, Shinya Yamamoto, Karen L. Schulze, , Hugo Jozef Bellen

The paper introduces three simplified CRISPR-based methods for DNA insertion in Drosophila, using short homology arms and ssDNA/dsDNA donors to generate transgenic constructs efficiently.

eLife · Nov 1, 2019Peer-reviewedGenomics